Mononitrates pp 270-276 | Cite as

Double-Blind, Cross-Over Study on the Antianginal Efficacy of IS-5-MN and ISDN s.r., a Multicenter Trial

  • G. Steinorth
  • U. Seidel
  • M. Glocke
  • H. J. Überbacher
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)


The hemodynamic effects and the antianginal efficacy of isosorbide-5-mononitrate (IS-5-MN, ISMO 20) in comparison with slow-release isosorbide dinitrate (ISDN) have been demonstrated in a number of controlled studies [1, 3, 4].


Coronary Heart Disease Angina Pectoris Isosorbide Dinitrate Angina Pectoris Attack Pretreatment Period 
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  1. 1.
    Bödigheimer K, Nowak FG, Delius W (1981) Vergleichende invasive Untersuchung über die Wirkung von Isosorbid-5-Mononitrat und Isosorbiddinitrat bei chronischer Herzinsuffizienz. Med Welt 32/14a:543–547PubMedGoogle Scholar
  2. 2.
    Keenan RE: Guidelines for the Clinical Evaluation of Anti-Anginal Drugs. FDA 78–3047Google Scholar
  3. 3.
    Müller G, Hacker W, Schneider B (1983) Intra-individual Comparison of the Action of Equal Doses of Isosorbide-5-endomononitrate, Slow-release Isosorbide Dinitrate and Placebo in Patients with Coronary Heart Disease. Klin Wochenschr 61:409–416PubMedCrossRefGoogle Scholar
  4. 4.
    Reifart N, Reifart F, Kaltenbach M, Bussmann W-D (1981) Vergleich der antianginösen Wirksamkeit und Wirkdauer von oral verabreichtem Isosorbiddinitrat (ISDN), Isosorbid-2-Mononitrat (IS-2-MN) und Isosorbid-5-Mononitrat (IS-5-MN). Med Welt 32/14 a:524–526PubMedGoogle Scholar
  5. 5.
    Überbacher HJ, Glocke M, Abshagen U (1983) Langzeitverträglichkeit und koronartherapeutische Wirksamkeit von Isosorbid-5-Mononitrat — Offene Multicenter-Studie unter Praxis-Bedingungen mit ISMO 20. MMW125, 4:76–78Google Scholar
  6. 6.
    Überbacher HJ, Steinorth G, Glocke M, Abshagen U (1983) An open, long-term multi-centre study of the antianginal efficacy and safety of isosorbide-5-mononitrate at low doses in patients with coronary heart disease. Pharmatherapeutica 3, 5:331–341PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. Steinorth
  • U. Seidel
  • M. Glocke
  • H. J. Überbacher

There are no affiliations available

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