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Mononitrates pp 188-189 | Cite as

Slow-Release Isosorbide-5-Mononitrate for the Treatment of Angina Pectoris: Duration of Effects

  • U. Thadani
  • S. Hamilton
  • S. Teague
  • D. Brady
  • B. White
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)

Abstract

Isosorbide dinitrate (ISDN) is widely used for the treatment of angina pectoris and has been shown to prolong exercise tolerance during acute and sustained therapy [1–8]. However, ISDN is poorly bioavailable after oral intake, and a marked inter-individual variation in plasma ISDN concentrations has been reported after oral doses during both acute and chronic therapy [4]. After oral ingestion, ISDN is rapidly metabolized into 2- and 5-mononitrates, both of which are biologically active. Now commercially available in Europe, isosorbide-5-mononitrate (IS-5-MN) has a half-life of 4–6 h and is almost 100% bioavailable after oral ingestion [9]. The latter makes this compound pharmacokinetically more desirable than its parent compound ISDN. Furthermore, a slow-release formulation of IS-5-MN providing high plasma levels for up to 24 h is now available which should theoretically offer advantages by exerting antianginal effects over a prolonged period of time.

Keywords

Angina Pectoris High Plasma Level Isosorbide Dinitrate Antianginal Effect Antianginal Efficacy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • U. Thadani
  • S. Hamilton
  • S. Teague
  • D. Brady
  • B. White

There are no affiliations available

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