Mononitrates pp 147-153 | Cite as

A Double-Blind Cross-Over Study on the Effectiveness and Possible Development of Tolerance during Long-Term Therapy with Isosorbide-5-Mononitrate or Isosorbide Dinitrate Slow-Release in Coronary Artery Disease

  • U. Rennhak
  • T. Riebesel
  • G. Biamino
Part of the International Boehringer Mannheim Symposia book series (BOEHRINGER)


It is well known that all types of nitrates are effective in angina pectoris syndrome. However, nearly 100-year old reports indicate that chronic treatment with high dosages of nitroglycerin may induce a tolerance with regard to its effect on reducing blood pressure [11, 12]. With the introduction of long-acting orally applicable nitrates the discussion has reopened with regard to whether long-term administration of multiple daily dosages of these drugs reduces the efficacy in angina pectoris syndrome. Although this hypothesis is supported by several studies [1, 5, 7, 10, 13, 14], the results are not generally accepted [2, 6, 8].


Angina Pectoris High Serum Concentration Isosorbide Dinitrate Anginal Attack Ergometric Exercise 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • U. Rennhak
  • T. Riebesel
  • G. Biamino

There are no affiliations available

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