Pharmacokinetics of IS-5-MN after Oral and Intravenous Administration in Patients with Hepatic Failure
Isosorbide-5-mononitrate (IS-5-MN) possesses complete absolute bioavailability due to the absence of any first-pass effect  in contrast to isosorbide dinitrate (ISDN) [2, 6,7, 8] which therefore has to be administered carefully in patients with impaired liver function, since higher concentrations than normal were found in these patients . The aim of the present study was to evaluate the role of the liver in the fate of IS-5-MN and its two metabolites, isosorbide-5-mononitrate-2-glucuro-nide (IS-5-MN-2-glu) and isosorbide (IS). The results obtained in the liver patients were compared with those of a group of six healthy volunteers.
KeywordsAlbumin Bilirubin Washout Doyle Antipyrine
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