Abstract
Isosorbide-5-mononitrate (IS-5-MN) possesses complete absolute bioavailability due to the absence of any first-pass effect [1] in contrast to isosorbide dinitrate (ISDN) [2, 6,7, 8] which therefore has to be administered carefully in patients with impaired liver function, since higher concentrations than normal were found in these patients [4]. The aim of the present study was to evaluate the role of the liver in the fate of IS-5-MN and its two metabolites, isosorbide-5-mononitrate-2-glucuro-nide (IS-5-MN-2-glu) and isosorbide (IS). The results obtained in the liver patients were compared with those of a group of six healthy volunteers.
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Akpan, W., Endele, R., Neugebauer, G., Steudel, H. (1985). Pharmacokinetics of IS-5-MN after Oral and Intravenous Administration in Patients with Hepatic Failure. In: Cohn, J.N., Rittinghausen, R. (eds) Mononitrates. International Boehringer Mannheim Symposia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70234-1_13
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DOI: https://doi.org/10.1007/978-3-642-70234-1_13
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