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The Cap Structure of Eukaryotic Messenger RNA and its Interaction with Cap-binding Protein

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Book cover Progress in Molecular and Subcellular Biology

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 9))

Abstract

This article is a review of what is known about the 7-methylguanosine-containing “cap” structure of eukaryotic messenger RNA and its participation in the initiation of protein synthesis. Particular attention will be paid to the protein which is thought to mediate the entry of mRNA into the cycle of protein synthesis by recognizing the cap structure, termed cap-binding protein (CBP). Previous review articles dealing with this or related topics include those of Shatkin (1976), Banerjee (1980), Ehrenfeld (1982), Penman (1982) and Nielsen et al. (1983). The primary focus of this review will be translational events. Topics which will not be treated include biosynthesis of caps (Rottman 1978; Banerjee 1980), the role of the cap structure in stabilization of mRNA against degradation (Shimotohno et al. 1977; Furuichi et al. 1977), and the CBP which is involved in initiation of transcription of influenza virus (Blaas et al. 1982).

An erratum to this chapter is available at http://dx.doi.org/10.1007/978-3-642-70203-7_5

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  1. Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, 20307, Washington D. C., USA

    Fred E. Hahn PH. D.

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Rhoads, R.E. (1985). The Cap Structure of Eukaryotic Messenger RNA and its Interaction with Cap-binding Protein. In: Hahn, F.E., Kopecko, D.J., Müller, W.E.G. (eds) Progress in Molecular and Subcellular Biology. Progress in Molecular and Subcellular Biology, vol 9. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70203-7_3

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