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Dyskinesia pp 9–18Cite as

Receptor-Binding Profiles of Neuroleptics

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Part of the book series: Psychopharmacology Supplementum ((PSYCHOPHARM,volume 2))

Abstract

Dopamine-receptor blockade seems to be a prominent effect of neuroleptics. Blockade of other receptors might, however, contribute to the therapeutic effect. A series of neuroleptics have been tested for affinity to DA D-1 and D-2 receptors, serotonin receptors (S2), α-adrenoceptors (α1), histamine receptors (H1, and muscarinic cholinergic receptors.

According to the affinity to DA D-1 and D-2 receptors, neuroleptics can be divided into different groups. Thioxanthenes have affinity for both D-1 and D-2 receptors; phenothiazines have affinity for D-2 receptors and considerably lower affinity for D-1 receptors; and butyrophenones, diphenylbutylpiperidines, and benzamides have affinity only for D-2 receptors.

Concerning affinity to other receptors the only consistent finding is affinity for S2 receptors.

The clinical significance of these findings is speculative. In several behavioral tests the D-1/D-2 classification is also observed, and it is suggested that D-1-receptor activation is responsible for dyskinesia, and that thioxanthenes — due to their D-1 receptor blocking effect — induce less dyskinesia than other neuroleptics.

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Author information

Authors and Affiliations

  1. H. Lundbeck A/S, Ottiliavej 7-9, DK-2500, Copenhagen-Valby, Denmark

    J. Arnt

Authors
  1. J. Hyttel
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  2. J.-J. Larsen
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  3. A. V. Christensen
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  4. J. Arnt
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Editor information

Editors and Affiliations

  1. Medical Research, Psychiatry and Neurology Services at the Veterans Administration Medical Center, USA

    Daniel E. Casey MD (Clinical Investigator, Associate Professor, Collaborative Scientist) (Clinical Investigator, Associate Professor, Collaborative Scientist)

  2. Departments of Psychiatry and Neurology at the Oregon Health Sciences University, 97207, Portland, OR, USA

    Daniel E. Casey MD (Clinical Investigator, Associate Professor, Collaborative Scientist) (Clinical Investigator, Associate Professor, Collaborative Scientist)

  3. Oregon Regional Primate Research Center, 97006, Beaverton, OR, USA

    Daniel E. Casey MD (Clinical Investigator, Associate Professor, Collaborative Scientist) (Clinical Investigator, Associate Professor, Collaborative Scientist)

  4. Intramural Research Program, National Institute of Neurological and Communicative Disorders and Stroke, Department of Health and Human Services, National Institute of Health, 20205, Bethesda, MD, USA

    Thomas N. Chase MD (Director) (Director)

  5. H. Lundbeck A/S, Ottiliavej 7-9, DK-2500, Copenhagen-Valby, Denmark

    Anne Vibeke Christensen MSc Pharm, DSc (Vice-President, Director of Research) (Vice-President, Director of Research)

  6. Department AEH, Sct. Hans Mental Hospital, DK-4000, Roskilde, Denmark

    Jes Gerlach MD

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© 1985 Springer-Verlag Berlin Heidelberg

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Hyttel, J., Larsen, JJ., Christensen, A.V., Arnt, J. (1985). Receptor-Binding Profiles of Neuroleptics. In: Casey, D.E., Chase, T.N., Christensen, A.V., Gerlach, J. (eds) Dyskinesia. Psychopharmacology Supplementum, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70140-5_2

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  • DOI: https://doi.org/10.1007/978-3-642-70140-5_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70142-9

  • Online ISBN: 978-3-642-70140-5

  • eBook Packages: Springer Book Archive

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