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Aggregation, Cohesion, Adhesion, Phagocytosis, and Morphogenesis in Dictyostelium — Mechanisms and Implications

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Microbial Adhesion and Aggregation

Part of the book series: Life Sciences Research Reports ((DAHLEM LIFE,volume 31))

Abstract

gp126, the contact site of vegetative Dictyolstelium cells, may be a receptor for bacterial phagocytosis. It is also involved in cell-cell adhesion and plays a role in size regulation during morphogenesis. It seems to work by a nonspecific mechanism because univalent anti- gp126 antibody inhibits phagocytosis of latex beads and adhesion to polystyrene surfaces. It is suggested that protein-carbohydrate interaction may be involved in bacterial phagocytosis but not in cell-cell adhesion.

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Refernces

  1. Beug, H.; Gerisch, G.; Kempff, S.; Riedel, V.; and Cremer, G. 1970. Specific inhibition of cell contact formations in Dictyostelium by univalent antibodies. Exp. Cell. Res. 63: 147–158.

    Article  PubMed  CAS  Google Scholar 

  2. Beug, H.; Katz, F.E.; and Gerisch, G. 1973. Dynamics of antigenic membrane sites relating to cell aggregation in Dictyostelium discoideum. J. Cell Biol. 56: 647–658.

    Article  PubMed  CAS  Google Scholar 

  3. Bonner, J.T. 1967. The Cellular Slime Molds. Princeton, NJ: Princeton University Press.

    Google Scholar 

  4. Born, G.V.R., and Garrod, D. 1968. Photometric demonstration of aggregation of slime mould cells showing effects of temperature and ionic strength. Nature 220: 616–618.

    Article  PubMed  CAS  Google Scholar 

  5. Chadwick, C.M.; Ellison, J.E.; and Garrod, D.R. 1983. A dual role for Dictyostelium contact site B in phagocytosis and developmental size regulation. Nature 307: 646–647.

    Article  Google Scholar 

  6. Chadwick, C.M., and Garrod, D.R. 1983. Identification of the cohesion molecule, contact sites B, of Dictyostelium discoideum. J. Cell Sci. 60: 251–266.

    PubMed  CAS  Google Scholar 

  7. Edwards, J.G. 1983. The biochemistry of cell adhesion. Prog. Surf. Sci. 13: 125–196.

    Article  CAS  Google Scholar 

  8. Garrod, D.R. 1972. Acquisition of cohesiveness by slime mould cells prior to morphogenesis. Exp. Cell. Res. 72: 588–591.

    Article  PubMed  CAS  Google Scholar 

  9. Garrod, D.R., and Born, G.V.R. 1971. Effect of temperature on the mutual adhesion of preaggregation cells of the slime mould, Dictyostelium discoideum. J. Cell Sci. 8: 751–765.

    PubMed  CAS  Google Scholar 

  10. Garrod, D.R., and Gingell, D. 1970. A progressive change in the electrophoretic mobility of preaggregation cells of the slime mould, Dictyostelium discoideum. J. Cell Sci. 6: 277–284.

    PubMed  CAS  Google Scholar 

  11. Garrod, D.R., and Nicol, A. 1981. Cell behavior and molecular mechanisms of cell adhesion. Biol. Rev. 56: 199–242.

    Article  PubMed  CAS  Google Scholar 

  12. Geltosky, J.E.; Weseman, J.; Bakke, A.; and Lerner, R.A. 1979. Identification of a cell surface glycoprotein involved in cell aggregation in D. discoideum. Cell 18: 391–398.

    Article  PubMed  CAS  Google Scholar 

  13. Gerisch, G. 1968. Cell aggregation and differentiation in Dictyostelium discoideum. Curr. Top. Dev. Biol. 3; 157–197.

    Article  PubMed  CAS  Google Scholar 

  14. Gingell, D., and Garrod, D.R. 1969. Effect of EDTA on electrophoretic mobility of slime mould cells and its relationship to current theories of cell adhesion. Nature 221: 192–193.

    Article  PubMed  CAS  Google Scholar 

  15. Glynn, P.J. 1981. A quantitative study of the phagocytosis of Escherichia coli by myxamoebae of the slime mould Dictyostelium discoideum. Cytobios 30: 153–166.

    PubMed  CAS  Google Scholar 

  16. Huffman, D.M., and Olive, L.S. 1964. Engulfment and anastamosis in the cellular slime molds (Acrasiales). Am. J. Botany 51: 465–471.

    Article  Google Scholar 

  17. Jaffé, A.R., and Garrod, D.R. 1979. Effect of isolated plasma membranes on cell-cell cohesion in the cellular slime mould. J. Cell Sci. 40: 245–256.

    PubMed  Google Scholar 

  18. Jaffé, A.R.; Swan, A.P.; and Garrod, D.R. 1979. A ligand-receptor model for the cohesive behaviour of Dictyostelium discoideum axenic cells. J. Cell Sci. 37: 157–167.

    PubMed  Google Scholar 

  19. Lee, K.-C. 1972. Cell electrophoresis of the cellular slime mould Dictyostelium discoideum. II. Relevance of the changes in cell surface charge density to cell aggregation and morphogenesis. J. Cell Sci. 10: 249–265.

    PubMed  CAS  Google Scholar 

  20. Marin, F.T.; Goyette-Boulay, M.; and Rothman, F.G. 1980. Regulation of development in Dictyostelium discoideum III. Carbohydrate- specific intercellular interactions in early development. Dev. Biol. 80: 301–312.

    Article  PubMed  CAS  Google Scholar 

  21. Müller, K., and Gerisch, G. 1978. A specific glycoprotein as the target site of adhesion blocking Fab in aggregating Dictyostelium cells. Nature 274: 445–449.

    Article  PubMed  Google Scholar 

  22. Müller, K.; Gerisch, G.; Fromme, I.; Mayer, H.; and Tsugita, A. 1979. A membrane glycoprotein of aggregating Dictyostelium cells with the properties of contact sites. Eur. J. Biochem. 99: 419–426.

    Article  PubMed  Google Scholar 

  23. Newell, P.C. 1977. Aggregation and cell surface receptors in cellular slime molds. In Microbial Interactions: Receptors and Recognition, ed. J.L. Reissig, Series B, vol. 3, pp. 3–57. London: Chapman and Hall Ldt.

    Google Scholar 

  24. Ochai, H.; Schwarz, H.; Merkl, R.; Wagle, G.; and Gerisch, G. 1982. Stage-specific antigens reacting with monoclonal antibodies against contact site A. A cell-surface glycoprotein of Dictyostelium discoideum. Cell Differ. 11: 1–13.

    Article  Google Scholar 

  25. Rosen, S.D., and Barondes, S.H. 1978. Cell adhesion in the cellular slime molds. In Specificity of Embryological Interactions. Receptors and Recognition, ed. D.R. Garrod, Series B, vol. 4, pp. 233–264. London: Chapman and Hall Ltd.

    Google Scholar 

  26. Shaffer, B.M. 1962. The Acrasina. Adv. Morphogen. 2; 109–182.

    Google Scholar 

  27. Steinemann, C., and Parish, R.W. 1980. Evidence that a developmentally regulated glycoprotein is target of adhesion-blocking Fab in reaggregating Dictyostelium. Nature 286: 621–623.

    Article  PubMed  CAS  Google Scholar 

  28. Swan, A.P. 1978. An inhibitor of cell cohesion from Dictyostelium discoideum. Ph. D. Thesis, University of Southampton.

    Google Scholar 

  29. Swan, A.P., and Garrod, D.R. 1975. Cohesive properties of axenically grown cells of the slime mould Dictyostelium discoideum. Exp. Cell Res. 93: 479–484.

    Article  PubMed  CAS  Google Scholar 

  30. Swan, A.P.; Garrod, D.R.; and Morris, D. 1977. An inhibitor of cell cohesion from axenically grown cells of the slime mould, Dictyostelium discoideum. J. Cell Sci. 28: 107–116.

    PubMed  CAS  Google Scholar 

  31. Vogel, G.; Thilo, L.; Schwarz, H.; and Steinhart, R. 1980. Mechanism of phagocytosis in Dictyostelium discoideum: Phagocytosis is mediated by different recognition sites as disclosed by mutants with altered phagocytotic properties. J. Cell Biol. 86: 456–465.

    Article  PubMed  CAS  Google Scholar 

  32. Waddell, D.R. 1982. A predatory slime mould. Nature 298: 464–466

    Article  Google Scholar 

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K. C. Marshall

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© 1984 Dr. S. Bernhard, Dahlem Konferenzen, Berlin

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Garrod, D.R. (1984). Aggregation, Cohesion, Adhesion, Phagocytosis, and Morphogenesis in Dictyostelium — Mechanisms and Implications. In: Marshall, K.C. (eds) Microbial Adhesion and Aggregation. Life Sciences Research Reports, vol 31. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70137-5_22

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  • DOI: https://doi.org/10.1007/978-3-642-70137-5_22

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70139-9

  • Online ISBN: 978-3-642-70137-5

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