Somatosensory Evoked Potential (SEP) in Myoclonus

  • H. Shibasaki
  • R. Neshige
  • Y. Yamashita
  • S. Tobimatsu
  • R. Fukui
Conference paper
Part of the Advances in Applied Neurological Sciences book series (NEUROLOGICAL, volume 1)


History of somatosensory evoked potential (SEP) in humans starts from Dawson’s finding of an extremely large EEG response to peripheral nerve stimulation in patients with myoclonic epilepsy (1). This giant SEP was shown to be characteristic of “pyramidal” myoclonus by Halliday (4) and of “cortical reflex” myoclonus by Hallett et al. (3). Physiological mechanisms of the giant SEP have not been elucidated. In this paper, therefore, diagnostic usefulness of SEP and physiological significance of the giant SEP will be reported.


Cortical Excitability Somatosensory Evoke Potential Myoclonic Epilepsy Peripheral Nerve Stimulation Thenar Muscle 
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  1. 1.
    Dawson, G.D. The relation between the electroencephalogram and muscle action potentials in certain convulsive states. J. Neurol. Neurosurg. Psychiat. 9: 5–22, 1946.PubMedCrossRefGoogle Scholar
  2. 2.
    Hallett, M., Chadwick, D., Adam, J., Marsden, C.D. Reticular reflex myoclonus: a physiological type of human post-hypoxic myoclonus. J. Neurol. Neurosurg. Psychiat. 40: 253–264, 1977.PubMedCrossRefGoogle Scholar
  3. 3.
    Hallett, M., Chadwick, D., Marsden, C.D. Cortical reflex myoclonus. Neurology 29: 1107–1125, 1979.PubMedGoogle Scholar
  4. 4.
    Halliday, A.M. The electrophysiological study of myoclonus in man. Brain 90: 241–284, 1967.PubMedCrossRefGoogle Scholar
  5. 5.
    Shibasaki, H., Kuroiwa, Y. Electroencephalographic correlates of myoclonus. Electroenceph. Clin. Neurophysiol. 39: 455–463, 1975.Google Scholar
  6. 6.
    Shibasaki, H., Yamashita, Y., Tsuji, S. Somatosensory evoked potentials. Diagnostic criteria and abnormalities in cerebral lesions. J. Neurol. Sci. 34: 427–439, 1977.PubMedCrossRefGoogle Scholar
  7. 7.
    Shibasaki, H., Yamashita, Y., Kuroiwa, Y. Electroencephalographic studies of myoclonus. Myoclonus-related cortical spikes and high amplitude somatosensory evoked potentials. Brain 101: 447–460, 1978.PubMedCrossRefGoogle Scholar
  8. 8.
    Sutton, G.G., Mayer, R.F. Focal reflex myoclonus. J. Neurol. Neurosurg. Psychiat. 37: 207–217, 1974.PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • H. Shibasaki
    • 1
  • R. Neshige
  • Y. Yamashita
  • S. Tobimatsu
  • R. Fukui
  1. 1.Dept. of Internal MedicineSaga Medical SchoolSagaJapan

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