Advertisement

Adult T-Cell Leukemia/Lymphoma and Its Clinical Subtypes from the Viewpoints of Viral Etiology

  • Masanori Shimoyama
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 115)

Abstract

Adult T-cell leukemia-lymphoma (ATL) has been accepted as a well-established clinieohematological disease entity with a special geographical distribution. Re- cent progress in research on ATL has disclosed that: (a) ATL cells have the inducer/helper T-cell phenotype (Hattori etal. 1981; Shimoyama etal. 1981, 1982b; Tobinai etal. 1982, 1983); (b) human T-cell leukemia virus (HTLV) and its associated antigens are always detected in cultured ATL cells (Pomsz etal. 1980; Hinuma etal. 1981; Miyoshi etal. 1982a; Hoshino etal. 1983a); (c) patients with ATL have antibody to HTLV (Hinuma etal. 1981, 1982b; Ichimaru etal. 1982; Robert-Guroff etal. 1982; Shimoyama etal. 1982a; Yunoki et al. 1982; Kinoshita et al. 1982b); (d) HTLV proviral DNA is inte- grated into the chromosomal DNA of cultured leukemia cell lines from ATL as well as of fresh ATL cells (Yoshida et al. 1982a, b; Hoshino et al. 1983a); (e) normal peripheral blood T cells can be transformed by cocultivation with an HTLV-producing cell line, and the same HTLV can be detected in the transformed cells (Miyoshi et al. 1981 a, b, 1982b; Hinuma et al. 1982a). In addition to these findings, seroepidemiological studies have revealed that anti-HTLV antibodies are frequently present in the sera of healthy adults who were born and lived in ATL-endemic areas (Hinuma etal. 1981, 1982b; Ichimaru etal. 1982), seropositive healthy adults may be carriers of HTLV (Miyoshi et al. 1982a; Ohkochi etal. 1984) and ATL has developed in anti-HTLV-positive healthy adults (Kinoshita et al. 1982a).

Keywords

Mycosis Fungoides Clinical Subtype Japan Scientific Society Leukemic Stage Monoclonal Integration 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hattori T, Uchiyama T, Toibana T, Takatsuki K, Uchino H (1981) Surface phenotype of Japanese adult T-cell leukemia cells characterized by monoclonal antibodies. Blood 58: 645–647PubMedGoogle Scholar
  2. Hinuma Y, Nagata K, Hanaoka M, Nakai M, Matsumoto T, Kinoshita, Shirakawa S, Miyoshi I (1981) Adult T-cell leukemia: Antigen in an ATL cell line and detection of antibodies to the antigen in human sera. Proc Natl Acad Sei USA 78: 6476–6480CrossRefGoogle Scholar
  3. Hinuma Y, Gotoh Y, Sugamura K, Nagata K, Goto T, Nakai M, Komoda H, Matsumoto T, Kinoshita K (1982a) A retrovirus associated with human adult T-cell leukemia: In vitro activation. Gann 73: 341–344PubMedGoogle Scholar
  4. Hinuma Y, Komoda H, Chosa T, Kondo T, Kohakura M, Takenaka T, Kikuchi M, Ichimaru M, Yunoki K, Sato I, Matsuo R, Takiuchi Y, Uchino H, Hamaoka M (1982b) Antibodies to adult T-cell leukemia-virus-associated antigen (ATLA) in sera from patients with ATL and controls in Japan: A nation-wide sero-epidemiologic study. Int J Cancer 29: 631–635PubMedCrossRefGoogle Scholar
  5. Hoshino H, Esumi H, Miwa M, Shimoyama M, Minato K, Tobinai K, Hirose M, Watanabe S, Inada N, Kinoshita K, Kamihira S, Ichimaru M, Sugimura T (1983a) Establishment and characterization of new cell lines derived from patients with adult T-cell leukemia. Proc Natl Acad Sci USA 80:6061–6065PubMedCrossRefGoogle Scholar
  6. Hoshino H, Shimoyama M, Miwa M, Sugimura T (1983b) Detection of lymphocytes producing a human retrovirus associated with adult T-cell leukemia by syncytia induction assay. Proc Natl Acad Sci USA 80:7337–7341CrossRefGoogle Scholar
  7. Ichimaru M, Kinoshita K, Kamihira S, Ikeda S, Yamada Y, Amagasaki T (1979) T-cell malignant lymphoma in Nagasaki district and its problems, Jpn J Clin Oncol 9 [suppl 1]:337–346Google Scholar
  8. Ichimaru M, Kinoshita K, Kamihira S, Yamada Y, Oyakawa Y, Amagasaki T, Kusano M (1982) Familial disposition of adult T-cell leukemia and lymphoma. In: Hanaoka M, Takatsuki K, Shimoyama M (eds) Adult T-cell leukemia and related diseases. Japan Scientific Societies, Tokyo, ( Gann monographs on cancer research, vol 28 )Google Scholar
  9. Karitani Y, Kobayashi T, Koh T, Iwata Y, Tanaka I, Minami N, Shirakawa S (1983) Adult T-cell leukemia on the east coast of Kii Peninsula - presentation of anti-ATLA-negative case. Jpn J Clin Oncol 13 [suppl 2]:269–280PubMedGoogle Scholar
  10. Kikuchi M, Mitsui T, Kozuru M, Uike N, Kurata T, Katsuta Y (1983) Case report of adult T-cell leukemia with preceding long-standing cutaneous involvement. Jpn J Clin Oncol 13 [suppl 2]:201–208Google Scholar
  11. Kinoshita K, Kamihira S, Yamada Y, Amagasaki T, Ikeda S, Momita S, Ichimaru M (1982) Adult T-cell leukemia-lymphoma in the Nagasaki district. In: Hanaoka M, Takatsuki K, Shimoyama M (eds) Adult T-cell leukemia and related diseases. Japan Scientific Societies, Tokyo (Gann monographs on cancer research, vol 28 )Google Scholar
  12. Kinoshita K, Hino S, Amagasaki T, Yamada Y, Kamihira S, Ichimaru M, Munehisa T, Hinuma Y (1982a)Development of adult T-cell leukemia-lymphoma (ATL) in two anti-ATL-associated antigen-positive healthy adults. Gann 73:684–685Google Scholar
  13. Kinoshita K, Amagasaki T, Yamada Y, Ikeda S, Momita S, Toriya K, Kamihira S, Ichimaru M (1983) Adult T-cell leukemia-lymphoma-related diseases in the Nagasaki district. Jpn J Clin Oncol 13: 215–230PubMedGoogle Scholar
  14. Matsumoto M, Momura K, Matsumoto T, Nishioka K, Hanada S, Furusho H, Kikuchi H, Kato Y, Utsunomiya A, Uematsu T, Iwashashi M, Hashimoto S, Yunoki K (1979) Adult T-cell leukemia-lymphoma in Kagoshima district, southwestern Japan: Clinical and hematological characteristics. Jpn J Clin Oncol 9 [suppl]:325–336Google Scholar
  15. Miyoshi I, Kubonishi I, Sumida M, Hiraki S, Tsubota T, Kimura I, Miyamoto K, Sato J (1980) A novel T-cell line derived from adult T-cell leukemia. Gann 71: 155–156PubMedGoogle Scholar
  16. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y (1981a) Type C virus-particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 294: 770–771PubMedCrossRefGoogle Scholar
  17. Myoshi I, Yosimoto S, Kubonishi I, Taguchi H, Shirashi Y, Ohtsuki Y, Akagi T (1981b) Transformation of normal human cord lymphocytes by co-cultivation with a lethally irradiated human T-cell line carrying type C virus particles. Gann 72:997–998Google Scholar
  18. Miyoshi I, Fujishita M, Taguchi H, Ohtsuki Y, Akagi T, Morimoto Y, Nagasaki A (1982a) Caution against blood trasfusion from donors seropositive to adult T-cell leukemia-associated antigens. Lancet 20: 684Google Scholar
  19. Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagata K, Hinuma Y (1981a) Type C virus-particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells. Nature 294: 770–771PubMedCrossRefGoogle Scholar
  20. Miyoshi I, Taguchi H, Kubinishi I, Yoshimoto S, Ohtsuki Y, Shiraishi Y, Akagi T (1982b) Type C virus-producing cell lines derived from adult T-cell leukemia. In: Hanaoka M, Takatsuki K, Shimoyama M (eds) Adult T-cell leukemia and related diseases. Japan Scientific Societies Press, Tokyo (Gann monographs on cancer research, vol 28 )Google Scholar
  21. Okochi K, Sato H, Hinuma Y (1984) A restrospective study on transmission of adult T-cell leukemia virus by blood transfusion: Seroconversion in reeipients. Vox Sang 46: 245–253PubMedCrossRefGoogle Scholar
  22. Poiesz BJ, Ruscetti FW, Gazdar AF, Bunn PA, Minna JD, Gallo RC (1980) Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sei USA 77: 7415–7419CrossRefGoogle Scholar
  23. Robert-Guroff M, Nakao Y, Notake K, Ito Y, Sliski A, Gallo RC (1982) Natural antibodies to human retrovirus HTLV in a Cluster of Japanese patients with adult T-cell leukemia. Science 215: 975–978PubMedCrossRefGoogle Scholar
  24. Shimoyama M, Minaot K, Saito H, Kitahara T, Konda C, Nakazawa M, Ishihara K, Watanabe S, Inada N, Nagatani T, Deura K, Mikata A (1979) Comparison of clinical, morphologic and imuunologic characteristics of adult T-cell leukemia-lymphoma and cutaneous T-cell lymphoma. Jpn J Clin Oncol 9 [Suppl]:357–372Google Scholar
  25. Shimoyama M, Minato K, Tobinai K (1981) Immunological, clinical and prognostic characteristics of Japanese T-cell lymphomas. In: Knapp W (ed) Leukemia markers. Academic, LondonGoogle Scholar
  26. Shimoyama M, Minato K, Tobinai K, Horikoshi N, Ibuka T, Deura K, Nagatani T, Ozaki Y, Inada N, Komoda H, Hinuma Y (1982a) Anti-ATLA (antibody to the adult T-cell leukemia cell-associated antigen)-positive hematologic malignancies in the Kanto district. Jpn J Clin Oncol 12:109–116Google Scholar
  27. Shimoyama M, Tobiani K, Hirose M, Minato K ( 1982 b) Cellular origin of T-cell malignancies. In: Hanaoka M, Takatsuki K, Shimoyama M (eds) Adult T-cell leukemia and related diseases. Japan Scientific Societies, Tokyo (Gann monographs on cancer research, vol 28 )Google Scholar
  28. Shimoyama M, Minato K, Tobinai K, Nagai M, Setoya T, Takenaka T, Ishihara K, Watanabe S, Hoshino H, Miwa M, Kinoshita M, Okabe S, Fukushima N, Inada N (1983a) A typical adult T-cell leukemia-lymphoma: Diverse clinical manifestations of adult T-cell leukemia-lymphoma. Jpn J Clin OncolGoogle Scholar
  29. Robert-Guroff M, Nakao Y, Notake K, Ito Y, Sliski A, Gallo RC (1982) Natural antibodies to human retrovirus HTLV in a Cluster of Japanese patients with adult T-cell leukemia. Science 215: 975–978PubMedCrossRefGoogle Scholar
  30. Miyoshi I, Fujishita M, Taguchi H, Ohtsuki Y, Akagi T, Morimoto Y, Nagasaki A (1982a) Caution against blood trasfusion from donors seropositive to adult T-cell leukemia-associated antigens. Lancet 20: 684Google Scholar
  31. Taguchi H, Miyoshi I (1983) Three cases of pre-adult T-cell leukemia. Jpn J Clin Oncol 13: 209–214PubMedGoogle Scholar
  32. Takatsuki K, Uchiyama T, Sagawa K, Yodoi J (1977) Adult T-cell leukemia in Japan. In: Seno S, Takaku F, Irino (eds) Topics in hematology. Excerpta Medica, AmsterdamGoogle Scholar
  33. Takenaka T, Nakamine H, Oshiro J, Maeda J, Kobori M, Hayashi T, Komoda H, Hinuma Y, Hanaoka M (1983) Scrologic and epdemiologic studies on adult T-cell leukemia (ATL): Specialreference to a comparison between patients with and without antibody to ATL-associated antigen. Jpn J Clin Oncol 13[Suppl 2]:257–268Google Scholar
  34. Tobinai K, Hirose M, Yamada H, Minato K, Shimoyama M (1982) Cellular origin of human lymphoid malignancies based on immunologic analysis of membrane differentiation antigens. Jpn J Clin Oncol 12: 73–90Google Scholar
  35. Tobinai K, Nagai M, Setoya T, Shibata T, Minato K, Shimoyama M (1983) Anti-ATLA (antibody to adult T-cell leukemia virus-associated antigen), highly positive in OKT4-positive mature T-cell malignancies. Jpn J Clin Oncol 13: 237–244PubMedGoogle Scholar
  36. Uchiyama T, Yodoi J, Sagawa K, Takatsuki K, Uchino H (1977) Adult T-cell leukemia: Clinical features and hematological features of 16 cases. Blood 50: 481–492PubMedGoogle Scholar
  37. Yamaguchi K, Nishimura H, Kawano F, Kohrogi H, Jono M, Miyamoto Y, Takatsuki K (1983) A proposal for smoldering adult T-cell leukemia - Diversity in clinical pictures of adult T-cell leukemia. Jpn J Clin Oncol 13: 189–199PubMedGoogle Scholar
  38. Yoshida M, Miyoshi I, Hinuma Y (1982a) Isolation and characterization of human adult T-cell leukemia and its implieation in the disease. Proc Natl Acad Sei USA 79: 2031–2035CrossRefGoogle Scholar
  39. Yoshida M, Miyoshi I, Hinuma Y (1982b) Isolation and characterization of retrovirus (ATLV) and its association with adult T-cell leukemia. In: Hanaoka M, Takatsuki K, Shimoyama M (eds) Adult T-cell leukemia and related diseases. Japan Scientific Societies, Tokyo (Gann monographs on cancer research, vol 28 )Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1985

Authors and Affiliations

  • Masanori Shimoyama
    • 1
  1. 1.Departments of Clinical Laboratory and Internal MedicineNational Cancer Center HospitalChuo-ku, TokyoJapan

Personalised recommendations