Skip to main content
SpringerLink
Log in
Book cover

Human T-Cell Leukemia Virus pp 211–220Cite as

Some Perspectives on the Molecular Mechanism of In Vitro Transformation and In Vivo Leukemogenesis by HTLV

  • Chapter

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 115))

Abstract

Human T-cell leukemia virus (HTLV) is a family of related T-cell lymphotropic retroviruses isolated from man. The first HTLV isolates, now called HTLV-I, have been obtained from patients with an aggressive form of T-cell malignancy now collectively called adult T-cell leukemia (ATL). In addition, HTLV isolates have been obtained from T-cell variants of hairy cell leukemia (see Robert-Guroff et al., this volume), called HTLV-II, and from patients with acquired immunodeficiency syndrome (AIDS), called HTLV-III (Wong-Staal and Gallo 1985). HTLV-I and HTLV-II have the capacity of immortalizing and “transforming” normal human T-cells in vitro (Markham et al. 1983; Miyoshi et al. 1981; Popovic et al. 1983), while HTLV-III is cytopathic. In this chapter, we will not deal with HTLV-III, but will attempt to define the mechanism of in vitro transformation and in vivo leukemogenesis by HTLV-I and HTLV-II, using several approaches:

  1. 1.

    Comparative analyses of different isolates to look for DNA sequences (genes?) that are in common or divergent and to correlate these findings with known biological activities and disease potential of these viruses.

  2. 2.

    Analyses of the integration and expression of viral genetic information in primary leukemic cells and in vitro transformed cells.

  3. 3.

    Examination of the mode of expression of cellular genes that may be relevant in T-cell transformation.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Arya S, Wong-Staal F, Gallo RC (1984) Human T-cell growth factor gene: Lack of expression in human T-cell leukemia virus infected cell lines. Science 223: 1086–1088

    Google Scholar 

  • Clark J, Hahn B, Mann DL, Wong-Staal F, Popovic M, Blattner WA, Gibbs NN, Gallo RC (to be published) Molecular and immunologic analysis of an HTLV-positive CLL case from Jamaica

    Google Scholar 

  • Clarke MF, Westin E, Schmidt D, Josephs SF, Ratner L, Wong-Staal F, Gallo RC, Reitz MS (1984) A human c-sis, cDNA clone from a human T-cell leukemia virus infected cell line transforms NIH 3T3 cells. Nature 308: 464–467

    Article  PubMed  CAS  Google Scholar 

  • Doolittle RF, Hunkapillar MW, Hood LE, Devare SG, Robbins KC, Aaronson SA, Antoniades HN (1983) Simian sarcoma virus one gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science 221: 275–277

    Article  PubMed  CAS  Google Scholar 

  • Fialkow PJ, Martin PJ, Najfeld V, Penfold GK, Jacobson RJ, Hansen JA (1981) Evidence for a multistep pathogenesis of chronic myelogenous leukemia. Blood 58: 158–163

    PubMed  CAS  Google Scholar 

  • Franchini G, Wong-Staal F, Gallo RC (1984) Human T-cell leukemia virus (HTLV) transcripts in fresh and cultured cells of patients with adult T-cell leukemia

    Google Scholar 

  • Fung YKT, Lewis WG, Crittenden LB (1983) Activation of the cellular oncogene c-erbB by LTR insertion: Molecular basis for induetion of erythroblastosis by avian leukosis virus. Cell 33: 357–368

    Article  PubMed  CAS  Google Scholar 

  • Gallo RC (1982) Regulation of human T-cell proliferation: T-cell growth factor, T-cell leukemias and lymphomas, and isolation of a new C-type retrovirus. In: Rosenberg SA, Kaplan HS (eds) Malignant lymphoms - etiology, immunology, pathology, treatment, vol 3. Academic, New York, p 201–218

    Google Scholar 

  • Gelmann EP, Franchini G, Manzari V, Wong-Staal F, Gallo RC (1984) Molecular cloning of a unique human T-cell leukemia virus ( HTLV-IIMO ). Proc Natl Acad Sei USA 81: 993–997

    Google Scholar 

  • Guo HG, Wong-Staal F, Gallo RC (1984) Novel viral sequences related to human T-cell leukemia virus in T-cells of a seropositive baboon. Science 223: 1195–1197

    Article  PubMed  CAS  Google Scholar 

  • Hahn BH, Gallo RC, Franchini G, Popovic M, Aoki T, Salahuddin S, Markham PD, Wong-Staal F (1974c) Clonal selection of HTLV infected cells in vivo and in vitro. Mol Biol Med 2: 29–36

    Google Scholar 

  • Hahn BH, Popvic M, Kalyanaraman VS, Shaw GM, LoMonico A, Weiss SH, Wong-Staal F, Gallo RC (1984a) Detection and characterization of an HTLV-II provirus in a patient with AIDS. In: Gottlieb MS, Groopman JE (eds) UCLA symposia on molecular and cellular biology, new series, vol 16. Alan R. Liss, New York

    Google Scholar 

  • Hahn BH, Shaw GM, Popovic M, LoMonico A, Gallo RC, Wong-Staal F (1984b) Molecular cloning and analysis of a new variant of human T-cell leukemia virus (HTLV-Ib) from an African patient with adult T-cell leukemia-lymphoma. Int J Cancer, in press

    Google Scholar 

  • Hayward WS, Neel BG, Astrin SM (1981) Induetion of lymphoid leukeosis by avian leukosis virus: Activation of a cellular “one” gene by promotor insertion. Nature 290: 475–480

    Google Scholar 

  • Josephs SF, Clarke MF, Westin EH, Reitz MS, Wong-Staal F (1984) Nucleotide sequence identity in the open reading frame of a transforming c-sis cDNA clone and that of the normal gene

    Google Scholar 

  • Kalyanaraman VS, Sarngadharan MG, Robert-Guruoff M, Miyoshi I, Blayney D, Golde D, Gallo RC (1982) A new subtype of human T-cell leukemia virus ( HTLV-II) associated with a T-cell variant of hairy cell leukemia. Science 218: 571–57

    Google Scholar 

  • Manzari V, Wong-Staal F, Franchini G, Colombini S, Gelmann EP, Oroszlan S, Staal S, Gallo RC (1983) Human T-cell leukemia-lymphoma virus (HTLV): Cloning of an integrated defective provirus and flanking cellular sequences. Proc Natl Acad Sei USA 80: 1574–1578

    Google Scholar 

  • Markham PD, Salahuddin SZ, Kalyanaraman VS, Popovic M, Sarin PS, Gallo RC (1983) Infection and transformation of fresh human umbilical cord blood cells by multiple sources of human T-cell leukemia-lymphoma virus ( HTLV ). Int J Cancer 31: 413–420

    Google Scholar 

  • Miyoshi I, Kubonishi I, Yoshimoto S, Akagi T, Ohtsuki Y, Shiraishi Y, Nagato K, Hinuma Y (1981) Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukemic T-cells. Nature 294: 770–771

    Article  PubMed  CAS  Google Scholar 

  • Miyoshi I, Yoshimoto S, Fujishita M, Taguchi H, Kubonishi I, Niiya K, Minezawa M (1982) Natural adult T-cell leukaemia virus infection in japanese monkeys. Lancet II: 658–659

    Google Scholar 

  • Noori-Daloii MR, Swift RA, Kung HJ (1981) Specific integration of REV pro viruses in avian bursal lymphomas. Nature 294: 574–576

    Article  PubMed  CAS  Google Scholar 

  • Nowell PC, Finan JB, Clark J, Sarin P, Gallo RC (1984) Karyotypic differences between primary cultures and cell lines from HTLV-positive leukemia/lymphoma. J Nat Can Inst 13: 849–852

    Google Scholar 

  • Oroszlan S, Sarngadharan MG, Copeland TD, Kalyanaraman VS, Gilden RV, Gallo RC (1982) Primary structure analysis of the major internal protein p24 of human type C T-cell leukemia virus. Proc Natl Acad Sei USA 79: 1291–1294

    Article  CAS  Google Scholar 

  • Popovic M, Lange-Wantzin G, Sarin PS, Mann D, Gallo RC (1983) Transformation of human umbilical cord blood T cells by human T-cell leukemia/lymphoma virus. Proc Natl Acad Sei USA 80: 5402–5406

    Article  CAS  Google Scholar 

  • Rowley JD, Haren JM, Wong-Staal F, Franchini G, Gallo RC, Blattner W (1984) The chromosome pattern in cells from HTLV positive patients. In: Gallo RC, Essex M, Gross L (eds) Human T-cell leukemia viruses. Cold Spring Harbor, New York, pp 85–89

    Google Scholar 

  • Saxinger WC, Lange-Wantzin G, Thomsen K, Lapin B, Yakoleva L, Li YW, Guo HG, Robert-Guroff M, Blattner WA, Ito Y, Gallo RC (1984) Human T-cell leukemia virus: a diverse family of related exogenous retroviruses of humans and old world primates. In: Gallo RC, Essex M, Gross L (eds) Human T-cell leukemia viruses. Cold Spring Harbor, New York, pp 323–330

    Google Scholar 

  • Seiki M, Hattori S, Hirayama Y, Yoshida M (1983) Human adult T-cell leukemia virus: Complete nucleotide sequence of the provirus genome integrated in leukemia cell DNA. Proc Natl Acad Sei USA 80: 3618–3622

    Google Scholar 

  • Shaw GM, Gonda MA, Flickinger GH, Hahn BH, Gallo RC, Wong-Staal F (1984) Conservation of a specific region of the virus genome in evolutionarily divergent members of the human T-cell leukemia virus family 81: 4544–4548

    CAS  Google Scholar 

  • Sodroski J, Trus M, Perkins D, Patarca R, Wong-Staal F, Gelmann EP, Gallo RC, Haseltine WA (1984) Repetitive structure in the long terminal repeat element of a type II human T-cell leukemia virus. Proc Natl Acad Sei USA 81: 4617–4621

    Article  CAS  Google Scholar 

  • Waldmann T, Broder S, Greene W, Sarin PS, Saxinger C, Blayney DW, Blattner WA, Goldman C, Frost K, Sharrow S, Depper J, Leonard W, Uchiyama T, Gallo RC (1983) A comparison of the funetion and phenotype of Sezary T-cells with human T-cell leukemia/lymphoma virus ( HTLV)-associated adult T-cell leukemia. Clin Res 31: 5474–5480

    Google Scholar 

  • Waterfield MD, Scrace GT, Whittle N, Stroobant P, Johnson A, Wasteson A, Westermark B, Heiding CH, Huang JS, Deuvel RF (1983) Platelet derived growth factor is structurally related to the putative transforming protein p24 of simian sarcoma virus. Nature 304: 35–39

    Article  PubMed  CAS  Google Scholar 

  • Westin EH, Wong-Staal F, Gelmann EP, Dalla Favera R, Papas TS, Lautenberger JA, Eva A, Reddy EP, Tronick SR, Aaronson SA, Gallo RC (1982) Expression of cellular homologues of retroviral onc genes in human hematopoetic cells. Proc Natl Acad Sei USA 79: 2490–2494

    Article  CAS  Google Scholar 

  • Whang-Peng J, Bunn PA, Knutsen T, Kao-Shan CS, Broder S, Jaffe E, Gelmann E, Blattner W, Lofters W, Young RC, Gallo RC (to be published) Cytogenetic studies in human T-cell lymphoma virus (HTLV) positive leukemia/lymphoma in the USA. J Nat Cancer Inst

    Google Scholar 

  • Wong-Staal F, Hahn B, Manzari V, Colombini S, Franchini G, Gelmann EP, Gallo RC (1983) A survey of human leukaemias for sequences of a human retrovirus, HTLV. Nature 302: 626–628

    Article  PubMed  CAS  Google Scholar 

  • Wong-Staal F, Gallo RC (1985) The family of human T-lymphotropic leukemia viruses (HTLV): HTLV-I as the cause of adult T-cell leukemia and HTLV-III as the cause of AIDS. In press

    Google Scholar 

  • Yoshida M, Seiki M, Yamaguchi K, Takatsuki K (1984) Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Nat Acad Sei, USA, 81: 2534–2537

    Google Scholar 

  • Zeuthen J, Klein G (1981) Some recent trends in studies of human lymphoid cells: B cells, Epstein- Barr virus and transformation. In: Neth R, Gallo RC, Graf T, Mannweiler K, Winkler K (eds) Modern trends in human leukemia IV. Cold Spring Harbor, New York, p 179–190

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD, 20205, USA

    Flossie Wong-Staal

Authors
  1. Flossie Wong-Staal
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

Rights and permissions

Reprints and permissions

Copyright information

© 1985 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Wong-Staal, F. (1985). Some Perspectives on the Molecular Mechanism of In Vitro Transformation and In Vivo Leukemogenesis by HTLV. In: Vogt, P.K. (eds) Human T-Cell Leukemia Virus. Current Topics in Microbiology and Immunology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70113-9_13

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-70113-9_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70115-3

  • Online ISBN: 978-3-642-70113-9

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation