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Structure and Function of the Genome of HTLV

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Human T-Cell Leukemia Virus

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 115))

Abstract

We are still in the early stages of discovery of the full range of biological activity of a newly discovered and most interesting family of human pathogens, the human T-cell leukemia viruses (HTLVs). This chapter is intended as a rough roadmap of the salient features of the viral genome. This overview is based in large measure on the sequence of one strain of HTLV that was obtained from lymphocytes of a patient with adult T-cell leukemia in Japan. Information is also drawn from protein sequence analysis and DNA sequence analysis of several other strains of HTLV isolated from patients with adult T-cell leukemia (ATLL) or acquired immune deficiency syndrome (AIDS) in our own laboratory. Similarities to other retroviruses are noted. The limits of our present knowledge will be outlined.

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Authors and Affiliations

  1. Laboratory of Biochemical Pharmacology, Dana Farber Cancer Institute, Charles A. Dana Cancer Center, 44 Binney Street, Boston, MA, 02115, USA

    William A. Haseltine, Joseph G. Sodroski & Roberto Patarca

Authors
  1. William A. Haseltine
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  2. Joseph G. Sodroski
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  3. Roberto Patarca
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Editor information

Editors and Affiliations

  1. Department of Microbiology, University of Southern California School of Medicine, 2025 Zonal Avenue HMR 401, 90033, Los Angeles, CA, USA

    Peter K. Vogt

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© 1985 Springer-Verlag Berlin · Heidelberg

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Haseltine, W.A., Sodroski, J.G., Patarca, R. (1985). Structure and Function of the Genome of HTLV. In: Vogt, P.K. (eds) Human T-Cell Leukemia Virus. Current Topics in Microbiology and Immunology, vol 115. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70113-9_12

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  • DOI: https://doi.org/10.1007/978-3-642-70113-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70115-3

  • Online ISBN: 978-3-642-70113-9

  • eBook Packages: Springer Book Archive

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