Calmodulin Structure and Function

  • L. J. Van Eldik
  • D. M. Watterson


Calcium is a mediator of many cellular responses and a regulator of major importance in cellular homeostasis. In order to elucidate the mechanisms of calcium control and the role of calcium in stimulus-response coupling, it is necessary to examine the cellular receptors for calcium. Thermodynamic, kinetic, and structural data strongly suggest that the cytoplasmic receptors for calcium acting as a biological messenger are a class of calcium-binding proteins referred to as calcium-modulated proteins. Calcium-modulated proteins reversibly bind calcium with dissociation constants in the micromolar range under relatively physiological conditions. Because most calcium-modulated proteins are intracellular and have dissociation constants that span the range of intracellular free calcium concentrations, they are postulated to be the major signal transducers of biological calcium signals. Most calcium-modulated proteins characterized to date are not enzymes but are effector proteins capable of transducing a calcium signal into a cellular response by their ability to regulate or modulate the activity of other macromolecules, including enzymes, in a calcium-dependent manner. Examples of calcium-modulated proteins are troponin C, parvalbumin, S100, vitamin D-dependent calcium-binding protein, and calmodulin.


Slime Mold Chicken Embryo Fibroblast Cyclic Nucleotide Phosphodiesterase Intracellular Free Calcium Concentration Amino Acid Sequence Difference 
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Copyright information

© Springer-Verlag, Berlin Heidelberg 1985

Authors and Affiliations

  • L. J. Van Eldik
  • D. M. Watterson
    • 1
  1. 1.Howard Hughes Medical Institute and Department of PharmacologyVanderbilt UniversityNashvilleUSA

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