Role of Calcium in Alpha-Adrenergic Regulation of Liver Function
The liver can be affected by the sympathetic nervous system via epinephrine and norepinephrine released into the bloodstream from the adrenal medulla or via norepinephrine released from adrenergic nerve endings within the liver. As is the case for other tissues of the body, the receptors to these catecholamines are of two major types designated α- and β-adrenergic receptors. The liver α-receptors are mainly of the α l -subtype (Hoffman et al. 1979,1981) and the liver β-receptors are mainly of the β 2 -subtype (Morgan et al. 1983).
KeywordsGlycogen Phosphorylase Liver Plasma Membrane Inositol Trisphosphate Hepatic Glucose Output Phosphorylase Activation
Unable to display preview. Download preview PDF.
- Berridge MJ (1984) Inositol trisphosphate and calcium mobilization. In: Bleasdale J (ed) Proceedings of Chilton conference on inositol and phosphoinositides. Humana Press, Clifton (In press)Google Scholar
- Blackmore PF, Hughes BP, Exton JH (1983a) Time course of a-adrenergic and vasopressin effects in isolated hepatocytes. In: Harris RA, Cornell NW (eds) Isolation, characterization and use of hepatocytes. Elsevier/North Holland Biomedical, Press, Amsterdam, pp 433–438Google Scholar
- Blackmore PF, Hughes BP, Charest R, Schuman EA, IV, Exton JH (1983b) Time course of a, adrenergic and vasopressin actions on phosphorylase activation, calcium efflux, pyridine nucleotide reduction, and respiration in hepatocytes. J Biol Chem 258: 10488–10494Google Scholar
- Denton RM, McCormack JG, Oviasu OA (1981) Short-term regulation of pyruvate dehydrogenase activity in the liver. In: Hue L, Van de Werve G (eds) Short-term regulation of liver metabolism. Elsevier/North Holland Biomedical. Press, Amsterdam, pp 159–174Google Scholar
- Exton JH (1983) a-Adrenergic agonists and Ca2+ movement. In: Cheung WY (ed) Calcium and cell function vol 4. Academic Press, London New York, pp 63–97Google Scholar
- Garrison JC (1983) Role of Cat+-dependent protein kinases in the response of hepatocytes to a-agonists, angiotensin II and vasopressin. In: Harris RA, Cornell NW (eds) Isolation, characterization, and use of hepatocytes. Elsevier/North Holland Biomedical Press, Amsterdam New York, pp 551–559Google Scholar
- Hutson NJ, Brumley FT, Assimacopoulos FD, Harper SC, Exton JH (1976) Studies on the a-adrenergic activation of hepatic glucose output. I. Studies on the a-adrenergic activation of phosphorylase and gluconeogenesis and inactivation of glycogen synthase in isolated rat liver parenchymal cells. J Biol Chem 251: 5200–5208PubMedGoogle Scholar
- Kirk CJ, Creba JA, Downes CP, Michell RH (1981) Hormone-stimulated metabolism of inositol lipids and its relationship to hepatic receptor function. Biochem Soc Trans 7: 377–379Google Scholar
- Putney JW (1984) Messages of the phosphoinositide effect. In: Bleasdale J (ed) Proceedings of Chilton conference on inositol and phosphoinositides. Humana Press, Clifton (In press)Google Scholar
- Strickland WG, Imazu M, Chrisman TD, Exton JH (1983) Regulation of rat liver glycogen synthase. Roles of Ca2+, phosphorylase kinase, and phosphorylase a. J Biol Chem 1:5490–5497Google Scholar
- Williamson JR, Thomas AP, Joseph SK (1984) The role of inositol trisphosphate in hormone-induced Ca2+ mobilization in liver. In: Bleasdale J (ed) Proceedings of Chilton conference on inositol and phosphoinositides. Humana Press, Clifton (In press)Google Scholar