The Role of Calcium in Prostaglandin and Thromboxane Biosynthesis
Prostaglandins and thromboxanes are biologically potent compounds derived from arachidonic acid. They are synthesized in a wide variety of tissues in response to various stimuli, and are known to modulate numerous physiological processes. These compounds are not stored within the cell, and their effects are restricted to the cell in which they are synthesized or to neighboring cells. Their precise mechanisms of action are not well understood; in general, their actions are believed to be mediated via cyclic AMP, or Ca2+.
KeywordsArachidonic Acid Human Platelet Phosphatidic Acid Arachidonic Acid Release Arachidonate Release
Unable to display preview. Download preview PDF.
- Ballou LR, Cheung WY (1984) Unsaturated fatty acids inhibit human platelet phospholipase A2 activity. Fed Proc 43: 1463Google Scholar
- Bergström S, Danilesson H, Samuelsson B (1964) The enzymatic formation of prostaglandin E2 from arachidonic acid. Prostaglandin and related factors. Biochim Biophys Acta 90: 207–210Google Scholar
- Berridge MJ (1982) A novel cellular signaling system based on the integration of phospholipid and calcium metabolism. In: Cheung WY (ed) Calcium and Cell Function, vol III. Academic, New York, pp 1–36Google Scholar
- Blackwell GJ, Duncombe WG, Flower RJ, Parsons MF, Vane JR (1977) The distribution and metabolism of arachidonic acid in rabbit platelets during aggregation and its modification by drugs. Br J Pharmacol 59: 35 3–366Google Scholar
- Flower RJ (1979) Prostaglandins and related compounds. In: Vane JR, Ferriera JH (eds) Anti-Inflammatory Drugs. Springer, Berlin Heidelberg New York, pp 374–422 (Handbook of Experimental Pharmacology, vol 50/I)Google Scholar
- Pickett WC, Jesse RL, Cohen P (1977) Initiation of phospholipase A2 activity in human platelets by the calcium ionophore A23187. Biochim Biophys Acta 486: 209–213Google Scholar
- Silver MJ, Bills TK, Smith JB (1978) Platelets and prostaglandins: the key role of platelet phospholipase A2 activity. In: deGaetano G, Gatalini S (eds) Platelets: A Multidisciplinary Approach. Raven, New York, pp 213–225Google Scholar
- Wong PY-K, Cheung WY (1982) Calmodulin stimulates thromboxane synthesis in human platelets: studies with thromboxane synthetase inhibitors. Adv Lipid Res 19: 447–452Google Scholar