Summary
A sufficient dose of NYC rabies virus obtained from canine salivary glands killed 100% of experimentally infected cats, approximately 70% of which showed the aggressive form of the disease. Virus titre and cat mortality remained unchanged after seven passages in mouse brains, but the aggressive form of rabies disappeared almost completely.
Strain NYC virus is poorly neutralized by serum antibodies in dogs, cats and cattle. These antibodies can be induced by various strains of vaccine virus.
As virus neutralization is essential for protection against infection, high post-vaccination antibody titres are of great importance for effective prophylaxis.
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References
Atanasiu P (1973) Quantitative assay and potency test of antirabies serum and immunoglobulin in Laboratory Techniques in Rabies, pp 314–318. Kaplan MM, Koprowski H (eds) World Health Organization, Geneva
Dean DJ, Abelseth MK (1973) The fluorescent antibody test in Laboratory Techniques in Rabies, pp 73–84. Kaplan MM, Koprowski H (eds) World Health Organization, Geneva
Jaeger O, Barth R (1979) Zur experimentellen Infektion der Katze mit dem Tollwutstraßenvirus NYC. Tierärztl Wochenschr, Berlin München 92:27–29
Kihm U, Lazarowicz M, Bommeli W, Zutter R (1982) Potency of two rabies vaccines in cats as determined by antibody assay and virulent virus challenge. Comp Immun Microbiol infect Dis 5: (1–3), 227–232
Koprowski H (1973) The mouse inoculation test, in Laboratory Techniques in Rabies. Kaplan MM, Koprowski H (eds) World Health Organization, Geneva, pp 85–93
Smith JS, Yager PA, Baer GM (1973) A rapid tissue culture test for determining rabies neutralizing antibody in Laboratory Techniques in Rabies. Kaplan MM, Koprowski H (eds) World Health Organization, Geneva, pp 354–357
Soulebot JP, Brun A, Chappuis G, Guillemin F, Petermann HG, Precausta P, Terré J (1981) Experimental rabies in cats: immune response and persistence of immunity. Cornell Vet 71:311–325
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© 1985 Springer-Verlag Berlin, Heidelberg
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Kihm, U., Zutter, R. (1985). Contribution to the Characterization of Rabies Street Virus Strain NYC. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_9
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DOI: https://doi.org/10.1007/978-3-642-70060-6_9
Publisher Name: Springer, Berlin, Heidelberg
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