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Control of Wildlife Rabies

  • J. Crick
  • F. Brown
  • A. A. King
  • E. W. Williams
  • G. Thompson
  • A. J. Fearne

Summary

The possibility of controlling terrestrial wild-life rabies by immunization rather than by population reduction has been under active consideration for the last 15–20 years. The idea is to provide vaccine in bait which is readily acceptable to the species concerned — for example, the fox in Western Europe and parts of North America.

Attention has been largely focussed on the idea of using live attenuated vaccines in the bait and recently highly successful field trials conducted in Switzerland have shown that the advance of the disease may be halted in this way.

However, none of the live vaccines at present available appears to be completely safe for all species and it is generally accepted that very strict measures of control must be applied if this procedure is extended.

We present results which suggest that it may be possible to use inactivated vaccines for the control of wild life rabies and thus avoid any risk associated with the widespread dispersal of live virus.

Keywords

Rabies Virus Live Vaccine Live Virus Oral Vaccination Rabies Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Résumé

Pendant les dernières 15–20 années, la possibilité de lutter contre la rage selvatique terrestre par la vaccination plutôt que par une réduction de la population animale a été fortement discutée. Le projet a pour but d’offrir aux animaux susceptibles des appâts contenant du vaccin — appâts qu’ils accepteraient volontairement — par exemple, aux renards en Europe Occidentale et dans certaines régions de l’Amérique du Nord.

L’attention a été surtout attirée à l’idée d’introduire dans l’appât des vaccins vivants atténués. Des essais récents sur le terrain en Suisse ont remporté du succès et indiquent que la distribution de la maladie puisse être arrêtée de cette façon.

Cependant, parmi des vaccins vivants actuellement disponibles, aucun ne parait complètement sans risques à toutes les espèces. Il est donc généralement accepté que des très fortes mesures de lutte doivent être adoptées si cette méthode est poussée plus loin.

Nous présentons des résultats qui indiquent la possibilité d’employer des vaccins inactivés pour lutter contre la rage selvatique. Ceux-ci éviteraient donc le risque considérable associé à la distribution sur une grande étendue de virus vivant.

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References

  1. 1.
    Atanasiu P, Metianu T, Bolanos A (1982) Evaluation d’une vaccination rabique expérimentale par la voie orale et intestinale avec des vaccins tués, concentrés et non-concentrés. Comparative Immunology, Microbiology and Infectious Diseases 5, 187–191.CrossRefGoogle Scholar
  2. 2.
    Baer GM (1962) “Oral vaccination in Foxes” EIS conference, Center for Disease Control, Atlanta, Georgia.Google Scholar
  3. 3.
    Baer GM (1975) Wildlife vaccination. In: The Natural History of Rabies II, ed. G.M. Baer, pp. 261–266. Academic Press, London.Google Scholar
  4. 4.
    Baer GM, Linhart SB, Dean DJ (1963) Annual report. Div. Lab. Res. New York State Health Department, Albany, New York.Google Scholar
  5. 5.
    Bijlenga G, Joubert L (1974) Haute pathogénicité pour la souris par voie digestive d’un composant viral du vaccin anti-rabique à virus modifié ERA/BHK. Bulletin de l’Académie Vétérinaire de France 47, 423–435.Google Scholar
  6. 6.
    Black JG, Lawson KF (1980) The safety and efficacy of immunizing foxes (Vulpes vulpes) using baits containing attenuated rabies virus vaccine. Canadian Journal of Comparative Medicine 44, 169–176.PubMedGoogle Scholar
  7. 7.
    Blancou J, Andral L, Aubert MFA, Artois M (1982) Vaccination du renard contre la rage par voie orale. Bulletin de l’Académie Vétérinaire de France 55, 351–359.Google Scholar
  8. 8.
    Clark HF (1978) Rabies viruses increase in virulence when propagated in neuroblastoma cell culture. Science 199, 1072–1075.PubMedCrossRefGoogle Scholar
  9. 9.
    Clark HF (1979) Factors affecting the virulence for mice of fixed rabies viruses. In ‘Mechanisms of viral pathogenesis and virulence’. Proceedings of the Fourth Munich Symposium on Microbiology, ed. P.A. Bachman, pp. 281–299, WHO Munich.Google Scholar
  10. 10.
    Debbie JG, Abelseth MK, Baer GM (1972) The use of commercially available vaccines for the oral vaccination of foxes against rabies. American Journal of Epidemiology 96, 231–235.PubMedGoogle Scholar
  11. 11.
    Hemmings C, Hemmings WA, Patey AL, Wood G (1977) The ingestion of dietary protein as large molecular mass degradation products in adult rats. Proceedings of the Royal Society London B. 198, 439–453.CrossRefGoogle Scholar
  12. 12.
    Hemmings WA (1978) The entry into the brain of large molecules derived from dietary protein. Proceedings of the Royal Society, London B, 200, 175–192.Google Scholar
  13. 13.
    Hemmings WA, Williams EW (1978) Transport of large breakdown products of dietary protein through the gut wall. Gut, 19, 715–723.PubMedCrossRefGoogle Scholar
  14. 14.
    Koprowski H (1954) Biological modification of rabies virus as a result of its adaptation to chicks and developing chick embryos. Bulletin of the World Health Organization 10, 709–724.PubMedGoogle Scholar
  15. 15.
    Lawson KF, Johnston DH, Patterson JM, Rhodes AJ. Studies on the immunization of wildlife against rabies. Fifth International Congress for Virology. Strasbourg, July 1981, P12/05.Google Scholar
  16. 16.
    Lawson KF, Johnston DH, Patterson JM, Black JG, Rhodes AJ, Zalan E (1982) Immunization of foxes Vulpes vulpes by the oral and intramuscular routes with inactivated rabies vaccine.Google Scholar
  17. 17.
    Nicholson KG, Bauer SP (1981) Enteric inoculation with ERA rabies virus; evaluation of a candidate wildlife vaccine in laboratory rodents. Archives of Virology 67, 51–56.PubMedCrossRefGoogle Scholar
  18. 18.
    Seifert J, Welter H, Lenz J, Brendel W (1979) Absorption of horse gamma globulin: correlation between immune-response and microcirculation in the gastrointestinal tract of dogs. In: Protein transmission through living membranes. Ed. W.A. Hemmings. Elsevier/ North Holland Biomedical Press, Amsterdam, pp. 275–284.Google Scholar
  19. 19.
    Smith JS, Yager PA, Baer GM (1973) A rapid tissue culture test for determining rabies neutralizing antibody. In Laboratory techniques in rabies. WHO monograph series 23, 354–357.Google Scholar
  20. 20.
    Steck F, Wandeler A, Bichsel P, Capt S, Haeflinger U, Schneider L (1982) Oral immunization of foxes against rabies. Comparative Immunology, Microbiology and Infectious Diseases 5, 165–171.CrossRefGoogle Scholar
  21. 21.
    Wachendörfer G, Kiefert C, Frost JW (1982) Safety tests with Flury HEP strain 675 in wild-living European mammals. Comparative Immunology, Microbiology and Infectious Diseases 5, 177–180.CrossRefGoogle Scholar
  22. 22.
    Wandeler AI, Bauder W, Prochaska S, Steck F (1982) Small mammal studies in a SAD baiting area. Comparative Immunology, Microbiology and Infectious Diseases 5, 173–176.CrossRefGoogle Scholar
  23. 23.
    WHO Conference on Surveillance and Control of Rabies, 15–19 Nov. 1977, Report 1978, Regional Office for Europe, WHO Copenhagen.Google Scholar
  24. 24.
    WHO Reports of consultations on oral and enteric mass immunization of wild life. Rabies Bulletin Europe 1/83. WHO Collaborating Centre for Rabies Surveillance and Research, pp. 10–14.Google Scholar
  25. 25.
    WHO unpublished working document. Rab. Res. 80.8. WHO Rabies/80–188.Google Scholar
  26. 26.
    WHO unpublished working document. Rab. Res. 82.16.Google Scholar
  27. 27.
    Wiktor TD (1980) Morbidity and Mortality Weekly Record 9–29, 86–87Google Scholar
  28. 28.
    Williams EW (1979) Transmission of dietary proteins through the adult rat gut. In: Protein Transmission through living membranes. ed. W.A. Hemmings. Elsevier/North Holland Biomedical Press, Amsterdam, pp. 259–268.Google Scholar

Copyright information

© Springer-Verlag Berlin, Heidelberg 1985

Authors and Affiliations

  • J. Crick
    • 1
  • F. Brown
    • 1
  • A. A. King
    • 2
  • E. W. Williams
    • 3
  • G. Thompson
    • 4
  • A. J. Fearne
    • 4
  1. 1.Animal Virus Research InstitutePirbright, Woking, SurreyUK
  2. 2.Central Veterinary LaboratoryMinistry of Agriculture, Fisheries and FoodSurreyUK
  3. 3.Department of ZoologyUniversity College of North WalesBangorUK
  4. 4.Brocades (G.B.) Ltd.Braintree, EssexUK

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