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Persistance des Anticorps Antirabiques, 3 Ans après Rappels de Vaccination

  • Conference paper
Rabies in the Tropics

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Summary

A systematic serological survey of a population was carried out before and after vaccination or boosters against Rabies with a Human Diploid Cell Rabies Vaccine (HDCV).

The professionally exposed population of 136 subjects, worked in an industrial slaughter house.

Assays were made by means of different methods:

  • Immunoenzymatic Test.

  • Rapid Fluorescent Focus Inhibition Test.

  • Cytopathic inhibition Test.

Titrations were done 3 years after any immunization in order to evaluate residual antibody titer which are probably essential elements in antirabies prevention.

This study suggested furthermore:

  1. 1°

    The great variability of individual data;

  2. 2°

    The great variability between different methods.

Résumé

Persistence des Anticorps Antirabiques dans une Population Vaccinée

La surveillance sérologique d’une population a été entreprise systématiquement avant et après vaccinations ou rappels contre la rage, par un vaccin préparé sur cellules diploïdes humaines. L’étude se fonde sur 136 personnes, exposées professionnellement et travaillant dans un abattoir industriel.

Ces titrages ont été effectués par diverses méthodes:

  • Test immunoenzymatique;

  • Test de réduction des foyers fluorescents;

  • Test de l’effect cytopathique.

Un titrage a été pratiqué 3 ans après toute intervention vaccinale: ceci permet d’apprécier le titre des anticorps résiduels; éléments vraisemblablement fondamentaux dans la prévention antirabique.

Cette étude révèle, par ailleurs:

  1. 1)

    La grande variabilité des résultats individuels.

  2. 2)

    L’importance des variations interméthodes.

Une étude de surveillance sérologique de la population vaccinée a été entreprise à l’Institut Pasteur de Lyon depuis 1976 — L’objet de ce rapport est l’évaluation de la réponse humorale d’une population vaccinée dans les conditions habituelles par un vaccin commercialisé, 3 ans après toute intervention vaccinale.

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Author information

Authors and Affiliations

  1. Institut Pasteur de Lyon, 77, Rue Pasteur, 69365, Lyon Cedex 2, France

    L. Lery, B. Yvernogeau, C. Bonfre & G. Bijlenga

  2. Ecole Nationale Vétérinaire Service des Maladies Infectieuses Lyon, France

    L. Joubert

  3. Centre de Toxico Vigilance Hospices Civils de Lyon, France

    N. Lery & A. Ponchon

Authors
  1. L. Lery
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  2. N. Lery
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  3. B. Yvernogeau
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  4. C. Bonfre
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  5. A. Ponchon
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  6. G. Bijlenga
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  7. L. Joubert
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Editor information

Editors and Affiliations

  1. Institute of Medical Virology and Immunology, University of Essen, Medical School, Hufelandstraße 55, 4300, Essen 1, Germany

    Ernst Kuwert

  2. Fondation Mérieux, 17 rue Bourgelat, 69002, Lyon, France

    Charles Mérieux

  3. The Wistar Institute, 36th Street at Spruce, Philadelphia, PA, 19140, USA

    Hilary Koprowski

  4. Veterinary Public Health, Division of Communicable Diseases, World Health Organization, 1211, Geneva, Switzerland

    Konrad Bögel (Chief) (Chief)

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© 1985 Springer-Verlag Berlin, Heidelberg

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Lery, L. et al. (1985). Persistance des Anticorps Antirabiques, 3 Ans après Rappels de Vaccination. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_27

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  • DOI: https://doi.org/10.1007/978-3-642-70060-6_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13826-6

  • Online ISBN: 978-3-642-70060-6

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