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Rabies in the Tropics pp 162–171Cite as

Effet Curatif Expérimental du Vaccin Antirabique Préparé sur Cellules de Rein de Veau Foetal (RVF)

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Summary

According to the recommandations of Habel (1973 WHO technical reports) and the French Academy of Medecine a study was carried out to evaluate the curative effect of antirabic vaccines.

The usual principles for the appreciation of the antirabic vaccine antigenic value is based on pre-exposure immunization.

The field-work estimation of both efficiency and safety of the vaccine was difficult to realise, due to the number of people to be treated.

Recent publications about post-exposure experiments suggest different mechanisms for pre-exposure immunization and post-exposure treatment.

The Renal Calf Embryo Cell Vaccine (RVF) presents a constant curative effect in mice. Furthermore, this vaccine is particularly interferogenic according to the curative effect noted.

Résumé

Selon les recommandations de Habel (rapports techniques de l’OMS 1973) et de l’Academie de Médecine Française, une étude de l’évaluation de l’activité curative des vaccins antirabiques a été entreprise.

Les tests habituels d’appréciation de la valeur antigénique des vaccins antirabiques sont tous basés sur le principe d’une vaccination avant contamination.

Les essais contrôlés, sur le terrain, de l’efficacité et de l’innocuité se révèlent, étant donné le nombre de sujets à traiter, difficilement réalisables.

Les études bibliographiques portant sur les expérimentations après contamination incitent à invoquer des mécanismes différents entre vaccinations préventives et traitements antirabiques. Le vaccin préparé sur cellule de rein de veau foetal, présente, chez la souris, une activité curative régulière; par ailleurs, et vraisemblablement en relation avec l’activité notée, ce vaccin est particulièrement interférogène.

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Author information

Authors and Affiliations

  1. Institut Pasteur de Lyon, 77, Rue Pasteur, 69365, Lyon Cedex 2, France

    L. Lery, G. Bijlenga & S. Hamadou

  2. Centre Hospitalier de Toxico-Vigilance, Hospices Civils de Lyon, France

    R. Bouguedour & L. Joubert

  3. Ecole Nationale Veterinaire de Lyon, Service des Maladies Contagieuses, Lyon, France

    N. Lery

Authors
  1. L. Lery
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  2. N. Lery
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  3. G. Bijlenga
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  4. R. Bouguedour
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  5. S. Hamadou
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  6. L. Joubert
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Editor information

Editors and Affiliations

  1. Institute of Medical Virology and Immunology, University of Essen, Medical School, Hufelandstraße 55, 4300, Essen 1, Germany

    Ernst Kuwert

  2. Fondation Mérieux, 17 rue Bourgelat, 69002, Lyon, France

    Charles Mérieux

  3. The Wistar Institute, 36th Street at Spruce, Philadelphia, PA, 19140, USA

    Hilary Koprowski

  4. Veterinary Public Health, Division of Communicable Diseases, World Health Organization, 1211, Geneva, Switzerland

    Konrad Bögel (Chief) (Chief)

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© 1985 Springer-Verlag Berlin, Heidelberg

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Lery, L., Lery, N., Bijlenga, G., Bouguedour, R., Hamadou, S., Joubert, L. (1985). Effet Curatif Expérimental du Vaccin Antirabique Préparé sur Cellules de Rein de Veau Foetal (RVF). In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_23

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  • DOI: https://doi.org/10.1007/978-3-642-70060-6_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13826-6

  • Online ISBN: 978-3-642-70060-6

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