Summary
Simultaneously with the development of a reassessed inactivated Polio Vaccine (Salk Vaccine) a new human rabies vaccine was researched, developed and produced.
The virus was cultivated on a VERO cell line grown on micro-carrier system, convenient for industrial scale production.
After BPL-inactivation and purification, the antigen suspension was diluted and freeze-dried. The efficacy and purity of this less costly cell-culture rabies vaccine will be useful for the protection of humans against this dangerous disease.
Résumé
Parallèlement au développement d’un nouveau vaccin polio inactivé (vaccin Salk), nous avons mis au point un nouveau vaccin antirabique à usage humain.
Le virus est cultivé sur des cellules VERO, sur un système de microporteurs, qui facilite la production à échelle industrielle.
Après l’inactivation par la BPL et la purification, la suspension de l’antigène est diluée puis lyophilisée. L’efficacité et la pureté de ce vaccin antirabique produit sur culture de cellules, plus économique, sera un précieux outil pour la protection des hommes contre ce fléau toujours présent.
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Bibliographie
Atanasiu P, Petrin P, Segre L, Manganas O (1982) Evaluation and comparative studies of inactivated rabies vaccines obtained in the heterologous diploīd and polyploīd cells (HAK, BHK and VERO). Develop biol Standard, 50:173–182
Montagnon BJ, Fanget B, Nicolas AJ (1981) The large scale cultivation of Vero cells in micro-carrier culture for virus vaccine production: preliminary results for killed poliovirus vaccine. Develop biol Standard, 47:55–64
Montagnon BJ, Fanget B, Vincent-Falquet JC (1983) Industrial scale production of inactivated poliovaccine prepared by culture of Vero cells on microcarrier. Reviews of Infectious Diseases (à paraître).
Tayot JL, Montagnon B (1972) Applications de la centrifugation zonale en immunologie virale. Aspects théoriques et pratiques. Symposium Européen de la Centrifugation Zonale (27 septembre 1972), ed Cité Nouvelle (Paris 1973)
Van Steenis G, Van Wezel AL (1982) Use of ATG-treated newborn rat for “in vivo” tumorigenicity testing of cell substrates. Develop biol Standard 50:37–46
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© 1985 Springer-Verlag Berlin, Heidelberg
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Montagnon, B.J., Fournier, P., Vincent-Falquet, J.C. (1985). Un Nouveau Vaccin Antirabique a Usage Humain: Rapport Préliminaire. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_19
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DOI: https://doi.org/10.1007/978-3-642-70060-6_19
Publisher Name: Springer, Berlin, Heidelberg
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