Purified Chick Embryo Cell (PCEC) Rabies Vaccine for Human Use — Laboratory Data

  • R. Barth
  • U. Bijok
  • H. Gruschkau
  • O. Jaeger
  • E. Weinmann
Conference paper


In order to overcome the difficulties and risks involved in production of HDC rabies vaccine for human use, a new tissue culture rabies vaccine for use in man has been developed. The Flury LEP-C25 strain was propagated in primary chick embryo cells (CEC), the tissue culture fluid was purified and concentrated by continuous density gradient centrifugation and inactivated by betapropiolactone. The antigen concentrates were tested by the modified antibody binding test and the vaccine adjusted to contain >2.5IU per dose. It was imposed that this vaccine should match the high standards of potency and tolerability achieved in the field by the HDC-vaccine. Therefore, this vaccine had to undergo numerous laboratory trials before clinical tests in man were considered.


Rabies Virus Protection Rate Rabies Vaccine Human Diploid Cell Antibody Induction 
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Copyright information

© Springer-Verlag Berlin, Heidelberg 1985

Authors and Affiliations

  • R. Barth
  • U. Bijok
  • H. Gruschkau
  • O. Jaeger
  • E. Weinmann
    • 1
  1. 1.Behring InstituteMarburg (Lahn)Germany

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