Summary
The early interaction of rabies virus with cells in culture has been investigated to define the nature of a cell surface receptor for the virus. It was found that rabies virus binds to a specific, saturable receptor on cells in culture and that this receptor has many of the characteristics which have been described for a receptor that specifically binds vesicular stomatitis virus. Rabies virus binding and replication in cultured cells were not inhibited by competitors of acetylcholine which bind to the nicotinic acetylcholine receptor (AChR), nor were cells which require high-density AChR any more infectable with rabies virus than cells lacking AChR. Therefore, we have concluded that rabies virus does not depend on the AChR complex for infection of susceptible cells in vitro.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Crowell RL, Landau BJ, Siak J-S (1981) In: Lonberg-Holm K, Philipson L (eds) „Virus Receptors“ Part 2. Animal Viruses, Series B, Vol 8, Chapman Hall, London, p 164
Murphy FA (1977) Arch Virol 54:279
Wiktor TJ, Clark HF (1975) In: Baer GM (ed) “The Natural History of Rabies” Vol 1, Academic Press, New York p 155
Lentz TL, Burrage TG, Smith AL, Crick J, Tignor GH (1982) Science 215:182
Watson HD, Tignor GH, Smith AL (1981) J Gen Virol 56:371
Heidmann T, Changeux J-P (1978) Ann Rev Biochem 47:317
Yaffe D, Saxel O (1977) Differentiation 7:159
Schultz M, Crowell RL (1980) J Gen Virol 46:39
Wiktor TJ (1974) Symp Ser Immunobiol Stand 21:102
Wunner WH, Reagan KJ, Koprowski H (1984) J Virol (in press)
Bennett JP Jr (1978) In: Yamamura Y, Enna SJ, Kuhar MJ (eds) “Neurotransmitter Receptor Binding”. Raven Press, New York, p 57
Schlegel R, Tralka TS, Willingham MC, Pastan I (1983) Cell 32:639
Schlegel R, Willingham MC, Pastan I (1982) J Virol 43:871
Thimmig RL, Hughes JV, Kinders RJ, Milenkovic AG, Johnson TC (1980) J Gen Virol 50:279
Perrin P, Portnoi D, Sureau P (1982) Ann Virol (Inst Pasteur) 133k:403
White J, Matlin K, Helenius A (1981) J Cell Biol 89:674
Reagan KJ, Wunner WH (1984) In: Bishop DHL, Compans R (eds) “Nonsegmented Negative Strand Viruses” (in press)
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin, Heidelberg
About this paper
Cite this paper
Reagan, K.J., Wunner, W.H. (1985). On the Nature of Rabies Virus-Cellular Receptor Interactions. In: Kuwert, E., Mérieux, C., Koprowski, H., Bögel, K. (eds) Rabies in the Tropics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70060-6_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-70060-6_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13826-6
Online ISBN: 978-3-642-70060-6
eBook Packages: Springer Book Archive