In blood smears (Figs. 3–6) the neutrophilic granulocytes can show fine, yet quite densly packed granules. More frequently, only sparse inclusions are present. While similar differences are observed in the monocytes, altogether storage here is more pronounced. Likewise, the eosinophils sometimes show discrete storage, i.e., slightly to moderately coarse, greenish granules. Such changes in the granulocytes and monocytes are often found in other MPSoses and are consequently of little importance. The lymphocytes are more significant; the proportion of affected cells differs from patient to patient (43%–90%), and the number of granules varies from cell to cell. They are usually fine and occasionally very densely packed. It is the distribution which is characteristic: the inclusions are for the most part diffusely spread throughout the cytoplasm, a phenomenon that can be observed even in the apparent absence of cytoplasmic seam. If plasma cells are present in the blood smear granules are rarely seen.
KeywordsPlasma Cell Blood Smear Reticulum Cell Neutrophilic Granulocyte Fine Granule
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