Variability of the Partition Coefficient in Relation to Cerebral Blood Flow with a Freely Diffusible Tracer
Cerebral blood flow (CBF) measurements with freely diffusible tracers have depended upon separate partition coefficients (lambda) for gray and white matter. As well, certain tracers have been considered inadequate in species with very high CBF as the lambda diminishes at high flow rates. Similarly, the relation of CBF in normal and pathologic circumstances related to the reliability of the measurement remains poorly understood.
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