Abstract
Cerebral blood flow (CBF) measurements with freely diffusible tracers have depended upon separate partition coefficients (lambda) for gray and white matter. As well, certain tracers have been considered inadequate in species with very high CBF as the lambda diminishes at high flow rates. Similarly, the relation of CBF in normal and pathologic circumstances related to the reliability of the measurement remains poorly understood.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Duncan CC, Lambrecht RM, Rescigno A, Shiue C-Y, Bennett GW, Ment LR (1983) The ramp injection of radiotracers for blood flow measurements by emission tomography. Phys. Med. Biol. 28: 963–972
Lambrecht RM, Duncan CC, Bennett GW, Ducote (1983) Method and Apparatus for injecting a substance into the bloodstream of a subject. U.S. Patent 4,409,966. October 18, 1983
Rescigno A, Lambrecht RM, Duncan CC (1983) Stochastic modelling of physiologic processes with radiotracers and positron emission tomography. In Applications of Physics to medicine and biology (Alberi, Bajzer and Baxa, editors). World Scientific Publ. Co., Singapore, Pages 303–318
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lambrecht, R.M., Rescigno, A., Duncan, C.C., Shiue, CY., Ment, L.R. (1985). Variability of the Partition Coefficient in Relation to Cerebral Blood Flow with a Freely Diffusible Tracer. In: Hartmann, A., Hoyer, S. (eds) Cerebral Blood Flow and Metabolism Measurement. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70054-5_57
Download citation
DOI: https://doi.org/10.1007/978-3-642-70054-5_57
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-70056-9
Online ISBN: 978-3-642-70054-5
eBook Packages: Springer Book Archive