Variability of the Partition Coefficient in Relation to Cerebral Blood Flow with a Freely Diffusible Tracer

  • R. M. Lambrecht
  • A. Rescigno
  • C. C. Duncan
  • C.-Y. Shiue
  • L. R. Ment

Abstract

Cerebral blood flow (CBF) measurements with freely diffusible tracers have depended upon separate partition coefficients (lambda) for gray and white matter. As well, certain tracers have been considered inadequate in species with very high CBF as the lambda diminishes at high flow rates. Similarly, the relation of CBF in normal and pathologic circumstances related to the reliability of the measurement remains poorly understood.

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References

  1. Duncan CC, Lambrecht RM, Rescigno A, Shiue C-Y, Bennett GW, Ment LR (1983) The ramp injection of radiotracers for blood flow measurements by emission tomography. Phys. Med. Biol. 28: 963–972PubMedCrossRefGoogle Scholar
  2. Lambrecht RM, Duncan CC, Bennett GW, Ducote (1983) Method and Apparatus for injecting a substance into the bloodstream of a subject. U.S. Patent 4,409,966. October 18, 1983Google Scholar
  3. Rescigno A, Lambrecht RM, Duncan CC (1983) Stochastic modelling of physiologic processes with radiotracers and positron emission tomography. In Applications of Physics to medicine and biology (Alberi, Bajzer and Baxa, editors). World Scientific Publ. Co., Singapore, Pages 303–318Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • R. M. Lambrecht
    • 1
  • A. Rescigno
    • 1
    • 2
  • C. C. Duncan
    • 2
  • C.-Y. Shiue
    • 1
  • L. R. Ment
    • 2
  1. 1.Chemistry DepartmentBrookhaven National LaboratoryUptonUSA
  2. 2.Yale UniversityUSA

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