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Evaluation of [125I]HIPDM as a Potential Tracer for Quantitative Measurement of Regional Cerebral Blood Flow

  • G. Lucignani
  • F. Fazio
  • A. Nehlig
  • R. Blasberg
  • C. S. Patlak
  • L. Anderson
  • H. F. Kung
  • C. Fieschi
  • L. Sokoloff

Abstract

External measurement of radioisotope concentration in brain tissue by positron emission tomography (PET) makes it possible to measure physiologic processes such as regional cerebral blood flow (rCBF) and cerebral metabolism in human subjects. The ability to achieve the same result with single photon emission computed tomography (SPECT), a technique which is much simpler and less costly than PET, is presently limited by the lack of suitable gamma-emitting labeled compounds and methods appropriate to the specific requirements of SPECT. While the development of methods for the measurement of rCBF by means of SPECT is presently the object of studies by several groups, this paper deals with the development of a specific tracer molecule and a kinetic model that might allow its use for the measurement of rCBF in man.

Keywords

Positron Emission Tomography High Performance Liquid Chromatography Single Photon Emission Compute Tomography Regional Cerebral Blood Flow Cereb Blood Flow 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • G. Lucignani
    • 1
  • F. Fazio
    • 2
  • A. Nehlig
    • 1
  • R. Blasberg
    • 3
  • C. S. Patlak
    • 4
  • L. Anderson
    • 5
  • H. F. Kung
    • 6
  • C. Fieschi
    • 7
  • L. Sokoloff
    • 1
  1. 1.Laboratory of Cerebral Metabolism, National Institute of Mental Health, U.S. Public Health ServiceDepartment of Health and Human ServicesBethesdaUSA
  2. 2.Institute S. RaffaeleUniversity of MilanoI-MilanoItaly
  3. 3.Department of Nuclear Medicine, Clinical Center, National Institutes of Health, U.S. Public Health ServiceDepartment of Health and Human ServicesBethesdaUSA
  4. 4.Theoretical Statistics and Mathematics Branch, Division of Biometry and Epidemiology, National Institute of Mental Health, U.S. Public Health ServiceDepartment of Health and Human ServicesBethesdaUSA
  5. 5.Laboratory of Medicinal Chemistry and Pharmacology, DTP, DCT, National Cancer Institute, NIH. U.S Public Health ServiceDepartment of Health and Human ServicesBethesdaUSA
  6. 6.Department of Nuclear Medicine at BuffaloSUNYBuffaloUSA
  7. 7.Department of Neurological SciencesUniversity of RomeI-RomeItaly

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