Evaluation of [125I]HIPDM as a Potential Tracer for Quantitative Measurement of Regional Cerebral Blood Flow
External measurement of radioisotope concentration in brain tissue by positron emission tomography (PET) makes it possible to measure physiologic processes such as regional cerebral blood flow (rCBF) and cerebral metabolism in human subjects. The ability to achieve the same result with single photon emission computed tomography (SPECT), a technique which is much simpler and less costly than PET, is presently limited by the lack of suitable gamma-emitting labeled compounds and methods appropriate to the specific requirements of SPECT. While the development of methods for the measurement of rCBF by means of SPECT is presently the object of studies by several groups, this paper deals with the development of a specific tracer molecule and a kinetic model that might allow its use for the measurement of rCBF in man.
KeywordsHigh Performance Liquid Chromatography Fractionation Propyl Clarification Antipyrine
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