Methodological Problems in the Clinical Application of the Atraumatic Xenon Techniques

  • M. D. O’Brien


The purpose of this paper is to outline some of the problems in the clinical application of the noninvasive xenon 133 inhalation and intravenous injection methods of cerebral blood flow measurement, and any subsequent mention of methodology refers to these two techniques. There are a number of pitfalls for the unwary in the clinical use of these methods, and these can be divided into two main groups. Firstly, the inappropriate use of equipment and overinterpretation of data and, secondly, possible errors due to assumptions made in the method itself.


Subtraction Technique Clearance Curve Cerebral Blood Flow Measurement Inhalation Time Arteriovenous Oxygen Difference 
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  2. Crawley JCW, O’Brien MD, Veall N (1971) The gamma spectrum subtraction technique applied to cerebral blood flow measurement by the inhalation of 133xenon, in: Brain and blood flow, ed. R.W. Ross Russell. Pitman, London, p 54–56Google Scholar
  3. O’Brien MD, Veall N (1974) Partition coefficients between blood and various cerebral tumours for Xenon-133. Phys Med Biol 19: 472PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • M. D. O’Brien
    • 1
  1. 1.Department of NeurologyGuy’s HospitalLondonGreat Britain

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