Rheological Determinants of Cerebral Blood Flow
Several factors have been identified as reducing cerebral blood flow (CBF) following cerebral infarction, among which the role of blood viscosity has attracted increasing interest during the past few years. An increase of whole blood viscosity may be produced by several factors, such as high hematocrit (hct), enhanced aggregation of platelets (PAG) and of red cells (RCA), loss of red cell elasticity (RCE), and an increase of the fibrinogen content. Likewise, a close correlation between whole blood viscosity and CBF has been established in normals as well as in cerebrovascular disease (CVD).
KeywordsCerebral Blood Flow Cerebral Infarction Blood Viscosity Fibrinogen Level Fibrinogen Content
Unable to display preview. Download preview PDF.
- Ott E, Lechner H (1982) Haemorheologic and haemodynamic aspects of cerebrovascular disease. Path Biol 30: 611–614Google Scholar
- Ott E, Ladurner G, Lechner H (1977) Relationship between disturbed rheological properties and cerebral haemodynamics in recent cerebral infarction. Progr Biochem 14: 349–352Google Scholar
- Ott E, Lechner H, Aranibar A et al. (1979) Impairment of rheologic conditions and cerebral blood flow in patients with cerebral vascular disease. In: Cerebral vascular disease 2. Meyer JS, Lechner H, Reivich M (eds) Excerpta Medica, AmsterdamGoogle Scholar