Neurology pp 477-486 | Cite as

Autoradiographic Distributions of Neurotransmitter Receptors in the Brain of Patients with Parkinson’s Disease and MPTP-induced Monkey Parkinsonism

  • S. Kito
  • R. Miyoshi
  • K. Mizuno
  • K. Nitta
  • H. Matsubayashi
  • Y. Yamamura
Conference paper


Parkinson’s disease is a slowly progressive degenerative disorder which is pathologically characterized by neuronal loss of the substantia nigra. Biochemically, deficiency of dopamine in the striatum resulting from degeneration and loss of dopaminergic neurons in the substantia nigra has been confirmed. In addition, from experiments using autopsied human materials [1–6], abnormalities have been reported in the dopaminergic as well as in the following systems: acetylcholine, GABA, serotonin, noradrenaline, and peptide-containing neurons. Recently, it was discovered that 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a by-product in the synthesis of MPPP (1-methyl-4-phenyl-4-propionoxy-piperidine), is selectively toxic to the zona compacta of the substantia nigra [7]. In this paper, we report on observed distributions of neurotransmitter receptors in brains of patients with Parkinson’s disease and those of primate models with MPTP-induced parkinsonism.


Substantia Nigra Globus Pallidus Ergot Alkaloid Neurotransmitter Receptor Zona Compacta 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • S. Kito
  • R. Miyoshi
  • K. Mizuno
  • K. Nitta
  • H. Matsubayashi
  • Y. Yamamura
    • 1
  1. 1.Third Department of Internal MedicineHiroshima University School of MedicineMinami-ku, HiroshimaJapan

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