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Parkinson’s Disease: Clinical Trials

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Neurology

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Abstract

Parkinson’s disease has been one of the most meticulously measured of all neurological disorders. Clinical trials have repeatedly played a crucial role in improving treatment, and because drugs are frequently employed as tools for the analysis of biological mechanisms, clinical trials have also made important contributions to an understanding of Parkinson’s disease. In this review of clinical trials in Parkinson’s disease, we shall discuss the following: diagnostic criteria, design of studies, methods of evaluation and analysis of results.

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References

  1. Anderson S et al. (1980) Statistical methods for comparative studies; techniques for bias reduction. Wiley, New York

    Book  Google Scholar 

  2. Armitage P (1957) Restricted sequential procedures. Biometria 44: 9–26

    Google Scholar 

  3. Armitage P (1960) Sequential medical trials. Blackwell, Oxford

    Google Scholar 

  4. Canter GJ, deLaTorre R, Mier M (1961) A method for evaluating disability in patients with Parkinson’s disease. J Nerv Ment Dis 133: 143–147

    Article  PubMed  CAS  Google Scholar 

  5. Chatfield C (1984) The analysis of time series: an introduction, 3rd edn. Chapman and Hall, London

    Google Scholar 

  6. Cochran WG (1983) Planning and analysis of observational studies. Wiley, New York

    Book  Google Scholar 

  7. Cox DR (1970) An analysis of binary data. Methuen, London

    Google Scholar 

  8. Duvoisin RC (1970) The evaluation of extra-pyramidal disease. In: de Ajuriagerra J (ed) Monoamines: noyaux gris centraux et syndrome de Parkinson. Masson, Paris, pp 313–325

    Google Scholar 

  9. Eisler T, Thorner MO, MacLeod RM, Kaiser DL, Calne DB (1981) Prolactin secretion in Parkinson’s disease. Neurology 31: 1356–1359

    PubMed  CAS  Google Scholar 

  10. England AC, Schwab RS (1956) Post-operative evaluation of selected patients with Parkinson’s disease. J Am Geriatr Soc 4: 1219–1232

    PubMed  Google Scholar 

  11. Evarts EV, Teravainen H, Calne DB (1981) Reaction time in Parkinson’s disease. Brain 106: 167–186

    Article  Google Scholar 

  12. Fahn S (in press) Methodology of drug trials in Parkinson’s disease. In: Capilideo R (ed) Methodology of drug trials in neurologic disorders

    Google Scholar 

  13. Fienbery SE (1983) The analysis of cross-classified categorial data, 2nd edn. MIT Press, Cambridge, Mass

    Google Scholar 

  14. Folkerts JF, Njiokiktjien CJ (1971) The influence of L-dopa on the postural regulation of Parkinson patients. 1st Symposium international de posturographie, October 19–22, Madrid

    Google Scholar 

  15. Hoaglin DC, Mosteller F, Tukey JW (eds) (1983) Understanding robust and exploratory data analysis. Wiley, New York

    Google Scholar 

  16. Hoehn MM, Yahr MD (1967) Parkinsonism: onset, progression and mortality. Neurology 17: 427–442

    PubMed  CAS  Google Scholar 

  17. Jansen EC, Larsen RE, Olesen MB (1982) Quantitative Romberg’s test. Acta Neurol Scand 66: 93–99

    Article  PubMed  CAS  Google Scholar 

  18. Kartzinel R, Perlow MD, Carter AC, Chase TN, Calne DB, Shoulson I (1976) Metabolic studies with Bromocriptine in patients with idiopathic Parkinsonism and Huntington’s Chorea. Trans Am Neurol Assoc 101: 53–56

    PubMed  CAS  Google Scholar 

  19. Knopp W (1968) Explorations in the assessment and meaning of the subclinical ex-trapyramidal effect of neuroleptic drugs. Pharmakopsychiatry 1: 54–62

    Article  Google Scholar 

  20. Knutsson E (1972) An analysis of Parkinsonian gait. Brain 95: 475–486

    Article  PubMed  CAS  Google Scholar 

  21. Lakke JPWF, Van Praag HM et al. (1972) Predictive value of the probenecid test for the effect of L-dopa therapy in Parkinson’s disease. Nature 236: 208–209

    CAS  Google Scholar 

  22. Larsen TA, LeWitt PA, Calne DB (1983) Theoretical and practical issues in assessment of deficits and therapy in Parkinsonism. In: Calne DB, Horowski R, McDonald RJ, Wuttke W (eds) Lisuride and other dopamine agonists. Raven Press, New York, pp 363–373

    Google Scholar 

  23. Larsen TA, Calne S, Calne DB (1984) Assessment of Parkinson’s disease. Clin Neuropharmacol 7 (2): 165–169

    Article  PubMed  CAS  Google Scholar 

  24. Martin WRW, Stoessl AJ, Adam MJ, Ammann W, Bergstrom M, Harrop R, Laihinen A, Rogers JG, Ruth TJ, Sayre CI, Pate BD, Calne DB (1985) Positron emission tomography in Parkinson’s disease. Glucose and DOPA metabolism. Adv Neurol (in press)

    Google Scholar 

  25. Miller RG Jr (1981) Survival analysis. Wiley, New York

    Google Scholar 

  26. Potvin AR, Tourtellotte WW (1975) The neurological examination: advancements in its quantitation. Arch Phys Med 56: 425–437

    PubMed  CAS  Google Scholar 

  27. Schoenberg BS, Anderson DW, Haerer AF (1985) Prevalence of Parkinson’s disease in the biracial population of Copiah County, Mississippi. Neurology 35: 841–845

    PubMed  CAS  Google Scholar 

  28. Tatton WG, Eastman MJ, Bedingham W, Verrier MC, Bruce IC (1984) Defective utilization of sensory input as the basis for bradykinesia, rigidity and decreased movement repertoire on Parkinson’s disease: a hypothesis. Can J Neurol Sci 11: 136–143

    PubMed  CAS  Google Scholar 

  29. Teravainen H, Calne DB (1980) Quantitative assessment of Parkinsonian deficits. In: Rinne UK, Klingler M, Stamm G (eds) Parkinson’s disease: current progress, problems and management. Elsevier, North-Holland, pp 145–164

    Google Scholar 

  30. Teravainen H, Evarts EV, Calne DB (1980) Studies of Parkinsonian movement: 1. Programming and execution of eye movements. Acta Neurol Scand 62: 137–148

    Article  PubMed  CAS  Google Scholar 

  31. Wagner HN, Burns HD, Dannais RF, Wong DF, Langstrom B, Duelfer T, Frost JJ, Ravart HT, Links JM, Rosenbloom SB, Lukas SE, Kramer AY, Kuhar MJ (1983) Imaging dopamine receptors in the human brain by positron tomography. Science 221: 1264–1266

    Article  PubMed  CAS  Google Scholar 

  32. Ward CD, Sanes JN, Dambrosia JM, Calne DB (1983) Methods for evaluating treatment in Parkinson’s disease. Adv Neurol 37: 1–7

    PubMed  CAS  Google Scholar 

  33. Webster DD (1968) Critical analysis of the disability in Parkinson’s disease. Mod Treat 5: 257–282

    PubMed  CAS  Google Scholar 

  34. Webster DD, Mortimer JA (1977) Failure of L-dopa to relieve activated rigidity in Parkinson’s disease. In: Messiha et al. (eds) Parkinson’s disease. Neurophysiological, clinical and related aspects. Plenum, New York, pp 297–313

    Google Scholar 

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Author information

Authors and Affiliations

  1. Division of Neurology, Department of Medicine, University of British Columbia, Health Sciences Centre Hospital, 2211 Wesbrook Mall, Vancouver, British Columbia, V6T 1W5, Canada

    D. B. Calne

Authors
  1. J. K. Tsui
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  2. M. Schulzer
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  3. D. B. Calne
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Editor information

Editors and Affiliations

  1. Abteilung Neurologie, R.W.T.H., Pauwelsstraße, 5100, Aachen, Germany

    Klaus Poeck

  2. Neurologische Universitätsklinik, Moorenstraße 5, 4000, Düsseldorf, Germany

    Hans-Joachim Freund

  3. Neurologische Universitätsklinik, Voßstraße 2, 6900, Heidelberg, Germany

    Heinz Gänshirt

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© 1986 Springer-Verlag Berlin Heidelberg

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Tsui, J.K., Schulzer, M., Calne, D.B. (1986). Parkinson’s Disease: Clinical Trials. In: Poeck, K., Freund, HJ., Gänshirt, H. (eds) Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70007-1_50

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  • DOI: https://doi.org/10.1007/978-3-642-70007-1_50

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-70009-5

  • Online ISBN: 978-3-642-70007-1

  • eBook Packages: Springer Book Archive

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