Neurology pp 340-348 | Cite as

Parkinson’s Disease: Clinical Trials

  • J. K. Tsui
  • M. Schulzer
  • D. B. Calne
Conference paper


Parkinson’s disease has been one of the most meticulously measured of all neurological disorders. Clinical trials have repeatedly played a crucial role in improving treatment, and because drugs are frequently employed as tools for the analysis of biological mechanisms, clinical trials have also made important contributions to an understanding of Parkinson’s disease. In this review of clinical trials in Parkinson’s disease, we shall discuss the following: diagnostic criteria, design of studies, methods of evaluation and analysis of results.


Movement Time Essential Tremor Plasma Prolactin Concentration Fixed Dose Level Predetermine Significance Level 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • J. K. Tsui
  • M. Schulzer
  • D. B. Calne
    • 1
  1. 1.Division of Neurology, Department of MedicineUniversity of British Columbia, Health Sciences Centre HospitalVancouverCanada

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