Abstract
In Parkinson’s disease, indirect evidence suggests that (a) clinical manifestation is a threshold phenomenon conditioned by progressive neuronal loss no longer compensated for normal functioning; (b) neuronal loss is basically an aging process, (c) the process is influenced not only by inherited predisposition but by effects of life-long exposure to various environmental factors; and (d) whereas a single major factor may be decisive in a few individuals exposed, most cases are caused by the combined or cumulative effects of many relatively minor factors [1]. In what follows, the risk factors which adversely affect the process leading to Parkinson’s disease are discussed, and our preliminary data for a better evaluation of such factors are presented.
This study was supported by a grant from the Intractable Diseases Project, Japan Ministry of Health and Welfare.
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References
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© 1986 Springer-Verlag Berlin Heidelberg
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Kondo, K. (1986). Epidemiology of Parkinson’s Disease — Relevance of the Risk Factors. In: Poeck, K., Freund, HJ., Gänshirt, H. (eds) Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70007-1_41
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DOI: https://doi.org/10.1007/978-3-642-70007-1_41
Publisher Name: Springer, Berlin, Heidelberg
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