Abstract
This overview is concerned with the epidemiology of motor neuron disease (MND) comprised of amyotrophic lateral sclerosis (ALS), progressive muscular atrophy (PMA), and progressive bulbar palsy (PBP). The mortality and morbidity distribution are described with emphasis on the geographic foci of the Western Pacific. The etiologic hypotheses are reviewed.
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References
Kurtzke JF, Kurland LT (1983) The epidemiology of neurologic disease. In: Baker AB (ed) Clinical neurology. Harper and Row, Philadelphia, chap 66
Mulder DW (1957) The clinical syndrome of amyotrophic lateral sclerosis. Proc Staff Meet Mayo Clin 32: 427
Bharucha N (1985) Geographic distribution of motor neurone disease in the U.S. and correlation with possible aetiologic factors. Proceedings of the international symposium on motor neuron disease, Bangalore, India, 29–30 Oct 1984
Juergens SM, Kurland LT, Okazaki H, Mulder DW (1980) ALS in Rochester, Minnesota, 1925–1977. Neurology 30: 463
Yoshida S, Mulder DW, Kurland LT, Chu C-P, Okazaki H (1986) Follow-up study on amyotrophic lateral sclerosis in Rochester, Minnesota, 1925 through 1984 (in press)
Mulder DW, Kurland LT, Offord KP, Beard CM (1985) Familial adult motor neuron disease (amyotrophic lateral sclerosis ). Neurology (in press)
Mulder DW, Espinosa RE (1969) Amyotrophic lateral sclerosis: comparison of the clinical syndrome in Guam and the United States. In: Norris FH Jr, Kurland LT (eds) Motor neuron diseases: research on amyotrophic lateral sclerosis and related disorders. Grune and Stratton, New York, p 12
Kurland LT, Mulder DW (1954) Epidemiologic investigations of amyotrophic lateral sclerosis: preliminary report on geographic distribution, with special reference to the Mariana Islands, including clinical and pathologic observations. Neurology 4: 355
Kurland LT, Choi NW, Sayre GP (1969) Implications of incidence and geographic patterns on the classification of amyotrophic lateral sclerosis. In: Norris FH Jr, Kurland LT (eds) Motor neuron diseases: research on amyotrophic lateral sclerosis and related disorders. Grune and Stratton, New York, pp 28–50
Gibbs CJ Jr, Gajdusek DC (1972) ALS, Parkinson’s disease and the ALS parkinsonian dementia complex on Guam: a review and summary of attempts to demonstrate infectious etiology. J Clin Pathol [Suppl] 6: 132
Anderson FH, Richardson EP Jr, Okazaki H, Brody JA (1979) Neurofibrillary degeneration on Guam: frequency in Chamorros and non-Chamorros with no known neurological disease. Brain 102: 65
Shiraki H (1969) The neuropathology of amyotrophic lateral sclerosis (ALS) in the Kii Peninsula and other areas of Japan. In: Norris FH Jr, Kurland LT (eds) Motor neuron diseases: research on amyotrophic lateral sclerosis and related disorders. Grune and Stratton, New York, p 80
Gajdusek DC, Salazar AM (1982) Amyotrophic lateral sclerosis and parkinsonism syndromes in high incidence among the Auyu and Jakai people of West New Guinea. Neurology 32: 107
Gajdusek DC, Garruto RM, Salazar AM (1980) Ecology of high incidence foci of motor neuron disease in eastern Asia and the western Pacific and the frequent occurrence of other chronic degenerative neurological diseases in these foci. Tenth international congress on tropical medicine and malaria, Manila, 9–15 Nov 1980, p 382
Yase Y (1977) The basic process of amyotrophic lateral sclerosis as reflected in Kii Peninsula and Guam. Exc Med Int Congr Ser 434: 413
Yanigahara R (1982) Heavy metals and essential minerals in motor neuron disease. In: Rowland LP (ed) Human motor neuron diseases. Raven, New York, p 233
Garruto RM (1985) Deposition of calcium and aluminum in central nervous system neurons: a primary or secondary phenomenon? Proceedings of international symposium on motor neuron disease, Bangalore, India, 29–30 Oct 1984
Polsky FI, Nunn PB, Bell EA (1972) Distribution and toxicity of α-amino-β-methyl- aminopropionic acid. Fed Proc 31: 1473
Proceedings of the third conference on the toxicity of cycads, Chicago, Illinois, 17 April 1964. Fed Proc 23: 1337
Kurland LT (1972) An appraisal of the neurotoxicity of cycad and the etiology of amyotrophic lateral sclerosis on Guam. Fed Proc 31: 1540
Proceedings of the sixth international cycad conference, Chicago, Illinois, USA, 17 April 1971. Fed Proc 31: 1465
Dastur DK (1964) Cycad toxicity in monkeys: clinical, biological and biochemical aspects. Fed Proc 23: 1368–1369
Reed DM, Brody JA (1975) Amyotrophic lateral sclerosis and parkinsonism dementia on Guam, 1945–1972.1: descriptive epidemiology. Am J Epidemiol 101: 287
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© 1986 Springer-Verlag Berlin Heidelberg
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Kurland, L.T., Mulder, D.W. (1986). Overview of Motor Neuron Disease. In: Poeck, K., Freund, HJ., Gänshirt, H. (eds) Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70007-1_39
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DOI: https://doi.org/10.1007/978-3-642-70007-1_39
Publisher Name: Springer, Berlin, Heidelberg
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