Neurology pp 126-130 | Cite as

The Dementias: A View to the Future

  • K. L. Bick
Conference paper

Abstract

Today we have had the opportunity to consider the broad array of current approaches to the dementias with especial concern for the commonest form of dementia, Alzheimer’s disease. As we look ahead to the next steps in our search for understanding, it is appropriate not only to look at where we are and where we have been, but also to take on that most dangerous of professions, that of the prophet. This discussion will focus on neurogenetic research strategies in Alzheimer’s disease.

Keywords

Peroxide Dementia Pyruvate Neurol Acetylcholine 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Breitner JCS, Folstein M (1984) Familial nature of Alzheimer’s disease. N Engl J Med 311: 192PubMedGoogle Scholar
  2. 2.
    Buckton KE, Whalley LJ, Lee M, Christie JE (1983) Chromosomic changes in Alzheimer’s presenile dementia. J Med Genet 20: 46–51PubMedCrossRefGoogle Scholar
  3. 3.
    Franke U, de Martinville B, Coussens L, Ullrich A (1983) The human gene for the β sub-unit of nerve growth factor is located on the proximal short arm of chromosome 1. Science 222: 1248–1251CrossRefGoogle Scholar
  4. 4.
    Gajdusek DC (1985) Hypothesis: interference with axonal transport of neurofilament as a common pathogenetic mechanism in certain diseases of the central nervous system. N Engl J Med 312: 714–719PubMedCrossRefGoogle Scholar
  5. 5.
    Heston LL, Mastri AR, Anderson VE, White J (1981) Dementia of the Alzheimer type: clinical genetics, natural history and associated conditions. Arch Gen Psychiatry 38: 1085–1090PubMedGoogle Scholar
  6. 6.
    Marotta CA, Sajdel-Sulkowska EM (1985) Factors affecting brain protein synthesis in Alzheimer’s disease. J Neurochem 44: S191Google Scholar
  7. 7.
    McLachlan-Crapper DR, Lewis PN, Lukiw WJ, Sima A, Bergeron C, deBoni U (1984) Chromatin structure in dementia. Ann Neurol 15: 329–334CrossRefGoogle Scholar
  8. 8.
    Morrison MR, Jamison S, Ojeda S, Pardue S, Griffin WST (1984) RNA isolation from Alzheimer’s brain. Soc Neurosci Abstr 10 (2): 1062Google Scholar
  9. 9.
    Ojika K, Appel SH (1983) Neurotrophic factors and Alzheimer’s disease. In: Biological aspects of Alzheimer’s disease. Banbury Report 15: 285–295Google Scholar
  10. 10.
    Robbins JH, Otsuka F, Tarone RE, Polinsky RJ, Brumback RA, Moshell AN, Nee LE, Ganges MB, Cayeux SJ (1983) Radiosensitivity in Alzheimer’s disease and Parkinson’s disease. Lancet i, 468–469CrossRefGoogle Scholar
  11. 11.
    Sajdel-Sulkowska EM, Marotta CA (1984) Alzheimer’s disease brain: alterations in RNA levels and in a ribonuclease-inhibitor complex. Science 225: 947–949PubMedCrossRefGoogle Scholar
  12. 12.
    Sheu K-FR, Kim Y-T, Blass JP, Weksler ME (1985), An immunochemical study of the pyruvate dehydrogenase deficit in Alzheimer’s disease brain. Ann Neurol 17: 444–449PubMedCrossRefGoogle Scholar
  13. 13.
    Terry RD (1976) Dementia: a brief and selective review. Arch Neurol 33: 1–4PubMedGoogle Scholar
  14. 14.
    White RL (1984) Human genetics. Lancet ii 1257–1262CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • K. L. Bick
    • 1
  1. 1.Nat. Inst. of Neurol. and Communicative Disorders and StrokesNational Institutes of HealthBethesdaUSA

Personalised recommendations