Abstract
Cell loss is one of the characteristic symptoms of aging of the central nervous system. In addition, it is one of the neuropathological features in Alzheimer’s disease (AD) and is commonly believed to underly the impairment of brain function found under these circumstances. Cell loss does not occur in a homogeneous way throughout the central nervous system [1] and it has often been proposed that ontogenetically and phylogenetically new structures would be affected more severely by cell loss in senescence and AD than would older structures [2]. However, few reliable data are available on this topic, while — to make things worse — cell loss in the human brain has generally been estimated by neuropathologists on the basis of the cell density in just a few microscopic sections.
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© 1986 Springer-Verlag Berlin Heidelberg
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Swaab, D.F., Fliers, E., Goudsmit, E. (1986). Differential Cell Loss in (Peptide) Neurons in the Anterior Hypothalamus with Aging and Alzheimer’s Disease: Lack of Changes in Cell Density. In: Poeck, K., Freund, HJ., Gänshirt, H. (eds) Neurology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-70007-1_14
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DOI: https://doi.org/10.1007/978-3-642-70007-1_14
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