Rhythmic Properties of Climbing Fiber Afferent Responses to Peripheral Stimuli

  • T. J. Ebner
  • J. R. Bloedel
Conference paper
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)

Abstract

An intriguing property of inferior olivary neurons is their tendency to discharge rhythmically at frequencies from 5–12 Hz (Armstrong 1974, Llinas 1981). This report focuses on the rhythmicity in the responses of Purkinje cells to climbing fiber inputs evoked by natural forepaw stimuli. In decereberate, unanesthetized cats the complex spike (CS) activity of Purkinje cells evoked by a forepaw displacement was averaged in post-stimulus time histograms (PSTH), and the autocorrelogram of the PSTH was calculated. The surgical procedures, recording techniques and peripheral input are described elsewhere (Ebner and Bloedel 1981, Ebner et al. 1983, Bloedel and Ebner 1984). Rhythmicity was defined as a minimum of three equally spaced peaks of complex spike activity, observed either in the PSTH or autocorrelogram. In 220 Purkinje cells with a complex spike response to the forepaw tap, 105 responded with a periodic discharge, the majority exhibiting a periodicity ranging from 100 to 160 ms. In 10 of 25 pairs of simultaneously recorded Purkinje cells the forepaw stimulus evoked periodicity in the complex spike discharge at a similar frequency. For some cells exhibiting only two peaks of CS activity, altering the stimulus duration did not alter the timing of the second peak of the CS response suggesting that the second peak of CS activity was due to a rhythmic activation of the climbing fiber afferent rather than a response to the “of” phase of the stimulus.

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References

  1. Armstrong DM (1974) Functional significance of connections of the inferior olive. Physiol Rev 54: 358–417PubMedGoogle Scholar
  2. Bloedel JR, Ebner TJ (1984) Rhythmic discharge of climbing fibre afferents in response to natural peripheral stimuli in the cat . J Physiol (in press)Google Scholar
  3. Bloedel JR, Ebner TJ, Yu QX (1983) Increased responsiveness of Purkinje cells associated with climbing fiber inputs to neighboring neurons. J Neurophysiol 50: 220–239PubMedGoogle Scholar
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  5. Ebner TJ, Yu QX, Bloedel JR (1983) Increase in Purkinje cell gain associated with naturally activated climbing fiber input. J Neurophysiol 50: 205–219PubMedGoogle Scholar
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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • T. J. Ebner
    • 1
  • J. R. Bloedel
    • 2
  1. 1.Depts. of Neurosurgery & PhysiologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Barrow Neurological InstituteSt.-Joseph’s Hospital and Medical CenterPhoenixUSA

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