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Climbing Fiber Function: Regulation of Purkinje Cell Responsiveness

  • Conference paper
Cerebellar Functions

Part of the book series: Proceedings in Life Sciences ((LIFE SCIENCES))

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Abstract

Since the intriguing theoretical paper by Marr (1969) on cerebellar cortical function, considerable attention has been directed towards the climbing fiber afferent system’s role in motor learning. According to this hypothesis (see also Gilbert (1975) and Albus (1971)), climbing fiber afferent input produces a persistent modification in the strength of the parallel fiber synapses on Purkinje cell dendrites. Subsequently it was proposed that this mechanism mediated the adaptation of the vestibuloocular reflex (VOR) gain (Ito 1972, 1979, Ito and Mijshita 1975, Robinson 1976). Supporting experiments showed that the inhibitory action of Purkinje cells on vestibular neurons was dependent on the integrity of the olivocerebellar system (Ito et al. 1978, 1979). Since these initial observations there has been considerable controversy concerning the role of the climbing fiber system in modifying the plasticity of the VOR (Miles et al. 1980, Demer and Robinson 1982, Lisberger 1982) and the efficacy of Purkinje cell action on their target neurons (Montarolo et al. 1981, Benedetti et al. 1983).

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Author information

Authors and Affiliations

  1. Barrow Neurological Institute St. Joseph’s Hospital and Medical Center, 350 West Thomas Rd., Phoenix, Arizona, 85013, USA

    J. R. Bloedel

  2. Depts. of Neurosurgery and Physiology University of Minnesota, Minneapolis, MN, 55455, USA

    T. J. Ebner

Authors
  1. J. R. Bloedel
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  2. T. J. Ebner
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Editor information

Editors and Affiliations

  1. Barrow Neurological Institute St. Joseph’s Hospital and Medical Center, 350 West Thomas Rd., 85013, Phoenix, Arizona, USA

    James R. Bloedel

  2. Neurologische Klinik, Universität Tübingen, Liebermeisterstraße 18-20, 7400, Tübingen, Germany

    Johannes Dichgans

  3. Institut für Hirnforschung, Universität Zürich, August-Forel-Straße 1, CH-8029, Zürich, Switzerland

    Wolfgang Precht

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© 1984 Springer-Verlag Berlin Heidelberg

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Bloedel, J.R., Ebner, T.J. (1984). Climbing Fiber Function: Regulation of Purkinje Cell Responsiveness. In: Bloedel, J.R., Dichgans, J., Precht, W. (eds) Cerebellar Functions. Proceedings in Life Sciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69980-1_17

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  • DOI: https://doi.org/10.1007/978-3-642-69980-1_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69982-5

  • Online ISBN: 978-3-642-69980-1

  • eBook Packages: Springer Book Archive

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