Cerebellar Hemispherectomy at Young Ages in Rats

  • A. Gramsbergen
  • J. Ijkema-Paassen
Part of the Proceedings in Life Sciences book series (LIFE SCIENCES)


Early animal experiments suggested that brain lesions at an early stage of brain maturation have less severe effects on later behavior than similar lesions in adult animals. From this so-called Kennard principle the notion has been derived that the capacity for functional compensation after brain trauma is greater for the immature than for the mature brain. However, more recent investigations — often involving a meticulous analysis of short and long term behavioral sequelae — rather provides evidence against the existence of any simple relation between early lesions and increased compensational capacity.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1984

Authors and Affiliations

  • A. Gramsbergen
  • J. Ijkema-Paassen
    • 1
  1. 1.Department of Developmental NeurologyUniversity HospitalGroningenThe Netherlands

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