Computerized Pharmacokinetic Evaluation of Antibiotics in Body Fluids and Tissues: An Overview

  • T. Bergan
Conference paper


Computerized pharmacokinetic evaluation in general aimes at a mathematical description of absorption, distribution, and metabolism of for instance antimicrobial agents. Pharmacokinetics uses established and objective criteria for the comparison of related drugs in health and disease. It can predict accumulation and the consequences of repetitive dosing and assist in generating suitable dosage regimens and steady state concentrations consistent with a probable therapeutic success and avoidance of side effects. In spite of very significant advances in the development of better antibacterial agents during the last decade, however, we need further information on the key factors governing penetration of antimicrobial agents to infected body sites in determining optimal dosage. In this presentation, I will deal with basic requirements for a pharmacokinetic assessment of antibiotics, including penetration of tissues and extravascular body sites.


Cystic Fibrosis Pharmacokinetic Model Peripheral Lymph Pharmacokinetic Assessment Serum Curve 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • T. Bergan
    • 1
  1. 1.Departments of Microbiology, Institute of Pharmacy and Aker HospitalUniversity of OsloOslo 3Norway

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