Methods for Detection of Antimicrobial-Induced Changes in the Normal Human Oropharyngeal and Colon Microflora

  • C. E. Nord
  • A. Heimdahl
Conference paper


The normal oropharyngeal and gastrointestinal microflora are stable ecosystems. Within a given person the microflora remains relatively constant over time. This ecosystem may however be disrupted. Irradiation of the head and neck causes changes in the oropharyngeal microflora and subsequently also in the gastrointestinal flora. Gastric surgery or pathologic conditions may affect normal peristalsis and can thus cause changes in the intestinal microflora. Hospitalization may also induce minor ecological changes. Ingestion of large bacterial inoculum may overhelm the resistance to new colonization and host defences (Nord et al. 1984). The most common and significant cause of disturbances in the oropharyngeal and gastrointestinal microflora is the administration of antimicrobial agents (Nord et al. 1984). The effect of antimicrobial agents on the patient’s normal micro flora can be separated into four general categories.


Antimicrobial Agent Volatile Fatty Acid Clostridium Difficile Intestinal Microflora Isobutyric Acid 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • C. E. Nord
    • 1
  • A. Heimdahl
    • 2
  1. 1.Department of Microbiology, Karolinska InstituteHuddinge HospitalHuddingeSweden
  2. 2.Department of Oral SurgeryNational Bacteriological LaboratoryStockholmSweden

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