Development of a Live Attenuated Vaccine Against Varicella

  • A. Gershon
Conference paper


Varicella zoster (VZ) virus was first isolated in tissue culture by Weller (1953), about 30 years ago. As Krugman (1984) has pointed out, vaccines against polio, measles, and rubella became licensed at the most within 16 years after it was possible to propagate the respective agents in the laboratory. The hepatitis B virus vaccine was developed even before that agent could be propagated. It might therefore seem surprising that there is, after 30 years, no vaccine licensed for prevention of disease caused by VZ virus. Fortunately, however, despite this long lag period a vaccine has been developed and it is being tested. This vaccine will probably become commercially available within the next few years.


Herpes Zoster Normal Child Varicella Vaccine Zoster Vaccine Vaccine Type 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Arbeter AM, Starr SE, Weibel RE, et al. (1982) Live attenuated varicella vaccine: immunization of healthy children with the OKA strain. J Pediatr 100:886–893PubMedCrossRefGoogle Scholar
  2. Bokay J (1909) Über den ätiologischen Zusammenhang der Varizellen mit gewissen Fällen von Herpes zoster. Wein Klin Wochenschr 22:1323–1326Google Scholar
  3. Brunell P (1977) Brunell’s brush-off. Pediatrics 59:954Google Scholar
  4. Brunell PA, Geiser C, Shehab Z, et al. (1982) Administration of live varicella vaccine to children with leukemia. Lancet 2:1069–1072PubMedCrossRefGoogle Scholar
  5. Cheatham WJ, Weller TH, Dolan TF, et al. (1956) Varicella: report of two fatal cases with necropsy, virus, isolation, and serologic studies. Am J Pathol 32:1015–1028PubMedGoogle Scholar
  6. Feldman S, Hughes WT, Daniel CB (1975) Varicella in children with cancer. Pediatrics 56:388–397PubMedGoogle Scholar
  7. Garland J (1943) Varicella following exposure to herpes zoster. N Engl J Med 228:336–337CrossRefGoogle Scholar
  8. Gershon AA (1980) Live attenuated varicella-zoster vaccine. Rev Infect Dis 2:393–407PubMedCrossRefGoogle Scholar
  9. Gershon AA, Steinberg S, Gelb L (1984) The National Institute of Allergy and Infectious Diseases Collaborative Varicella Vaccine Study Group. Efficacy of varicella vaccine in children with leukemia in remission. JAMA 252:355–362PubMedCrossRefGoogle Scholar
  10. Izawa T, Ihara T, Hattori A, et al. (1977) Application of a live varicella vaccine in children with acute leukemia or other malignant diseases. Pediatrics 60:805–809PubMedGoogle Scholar
  11. Krugman S (1984) Evaluation of hepatitis B vaccine. Presented at 4th international Symposium on rapid methods and automation in microbiology and immunology, BerlinGoogle Scholar
  12. Martin JH, Dohner DE, Wellinghof WJ, et al. (1982) Restriction endonuclease analysis of varicellazoster vaccine virus and wild-type DNAs. J Med Virol 9:69–76PubMedCrossRefGoogle Scholar
  13. Plotkin S (1977) Varicella vendetta: Plotkin’s plug. Pediatrics 59:953–954PubMedGoogle Scholar
  14. Ross AH, Lenchner E, Reitman G (1962) Modification of chickenpox in family contacts by administration of gamma globulin. N Engl J Med 267:369–376PubMedCrossRefGoogle Scholar
  15. Sakurai M, Ihara T, Ito M, et al. (1982) Application of a live varicella vaccine in children with acute leukemia. In: Herpes virus: clinical pharmacological and basic aspects. Shiota, Cheng, Prusoff (eds) Exerpta Medica, Amsterdam, pp 87–93Google Scholar
  16. Straus SE, Hay J, Smith H, et al. (1983) Genome differences among varicella-zoster virus isolates. J Gen Virol 64:1031–1041PubMedCrossRefGoogle Scholar
  17. Takahashi M (1983) Chickenpox virus. Adv Virus Res 28:285–356PubMedCrossRefGoogle Scholar
  18. Takahashi M, Otsuka T, Okuno Y, et al. (1974) Live vaccine used to prevent the spread of varicella in children in hospital. Lancet 2:1288–1290PubMedCrossRefGoogle Scholar
  19. Weibel R, Kuter B, McLean A, et al. (1984) Efficacy of varicella vaccine in normal children. N Engl J Med (to be published)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • A. Gershon
    • 1
  1. 1.New York University Medical CenterNew YorkUSA

Personalised recommendations