Development of a Live Attenuated Vaccine Against Varicella
Varicella zoster (VZ) virus was first isolated in tissue culture by Weller (1953), about 30 years ago. As Krugman (1984) has pointed out, vaccines against polio, measles, and rubella became licensed at the most within 16 years after it was possible to propagate the respective agents in the laboratory. The hepatitis B virus vaccine was developed even before that agent could be propagated. It might therefore seem surprising that there is, after 30 years, no vaccine licensed for prevention of disease caused by VZ virus. Fortunately, however, despite this long lag period a vaccine has been developed and it is being tested. This vaccine will probably become commercially available within the next few years.
KeywordsPlacebo Arthritis Hepatitis Europe Leukemia
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