Circulating Steroids in Male Rats Following Inhalation of n-Alcohols

  • A. M. Cameron
  • K. Zahlsen
  • E. Haug
  • O. G. Nilsen
  • K. B. Eik-Nes
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

The effect of inhaled methanol, ethanol, n-propanol and n-butanol on male reproductive function as measured by the serum concentration of circulating T (testosterone) and LH (luteinizing hormone) has been investigated. The animals were exposed to concentrations of these alcohols equal to the current threshold limit values in industry (methanol: 200 ppm, ethanol: 1000 ppm, n-propanol, n-butanol: 50 ppm) 6 h a day for up to 1 week. A significant depression in the concentration of circulating T was found after the first 6 h exposure to the respective alcohols with restoration after a recovery period of 18 h, except in rats exposed to n-butanol where a depression of 48 could still measured. The concentration of LH was within the normal range in all experimental groups whereas corticosterone was increased after exposure to nbutanol. Exposure for 1 week was not associated with any significant inability of the rat testis to produce T.

Key words

Inhalation n-Alcohols Testosterone Luteinizing hormone Corticosterone 

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References

  1. Cameron AM, Nilsen OG, Haug E, Eik-Nes KB (1984) Circulating concentrations of testosterone (T), luteinizing hormone and follicle stimulating hormone in male rats after inhalation of methanol. Arch. Toxicol. Suppl 7, 441–443CrossRefGoogle Scholar
  2. Chapin RE, Breese GR, Mueller RA (1980) Possible mechanisms of reduction of plasma luteinizing hormone by ethanol. J. Pharm. Exp. Ther. 222, 6–10Google Scholar
  3. Gordon GG, Southren AL, Lieber CS (1979) Hypogonadism and feminization in the male A triple effect of alcohol. Alc. Clin. Exp. Res. 3, 210–212CrossRefGoogle Scholar
  4. Mendelson JH, Ellingboe J, Mello NK, Kuehnle J (1978) Effects of alcohol on plasma testosterone and luteinizing hormone levels. Alc. Clin. Exp. Res. 2, 255–258CrossRefGoogle Scholar
  5. Mendelson JH, Mello, NK, Ellingboe J (1977) Effects of acute alcohol intake on pituitary-gonadal hormones in normal human males. J. Pharmacol. Exp. Ther. 202, 676–682PubMedGoogle Scholar
  6. Van Thiel DH, Cacaler J, Lester R, Goodman MD (1975) Alcohol induced testicular atrophy: An experimental model for hypogonadism occurring in chronic alcoholic men. Gastroenterology 69, 326–332PubMedGoogle Scholar
  7. White LR, Marthinsen ABL, Richards RJ, Eik-Nes KB, Nilsen OG (1983) Biochemical and cytological studies of rat lung after inhalation of methanol. Toxicol. Lett. 17, 1–5PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • A. M. Cameron
    • 1
  • K. Zahlsen
    • 2
  • E. Haug
    • 3
  • O. G. Nilsen
    • 2
  • K. B. Eik-Nes
    • 1
  1. 1.Department of BiophysicsUniversity of TrondheimTrondheimNorway
  2. 2.Dept. of Pharmacology and ToxicologyUniversity of TrondheimTrondheimNorway
  3. 3.The Hormone LaboratoryAker HospitalN-Oslo 5Norway

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