The Metabolism of Some Xenobiotics in Germ-Free and Conventional Rats

  • R. Macholz
  • M. Kujawa
  • J. Schulze
  • H. J. Lewerenz
  • W. Schnaak
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

The different participation of the gastrointestinal microflora in the biotransformation of gamma-hexachlorcyclohexane (gamma-HCH), azobenzene and the isolated glucosinolate progoitrin was studied. Marked dehydrochlorination of gamma-HCH to gamma-pentachlorcyclohexene (PCCH) also occurs without participation of the microflora. Azobenzene was reduced in germ-free (g) and conventional (c) rats to hydrazobenzene but was split to aniline only in c-rats. Progoitrin was split with and without the influence of the microflora, but the splitting was more complete in rats with intact gastrointestinal flora.

Key words

Gastrointestinal microflora Biotransformation Hexachlor-cyclohexane Azobenzene Progoitrin 

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References

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • R. Macholz
    • 1
  • M. Kujawa
    • 1
  • J. Schulze
    • 1
  • H. J. Lewerenz
    • 1
  • W. Schnaak
    • 1
  1. 1.Central Institute of Nutrition of the Academy of Sciences of the GDRBergholz-RehbrückeGDR

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