Increased Response of Cytochrome P-450 Dependent Biotransformation Reactions in Rat Liver to Repeated Administration of Inducers

  • U. Kleeberg
  • M. Sommer
  • W. Klinger
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

A single intraperitoneal administration of 3-methylcholanthrene (3 MC) or β-naphthoflavone (BNF) increased aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin 0-deethylase (EROD) activities. Following a second administration of both inducers 3–4 weeks later, the extent of induction was considerably greater. Such a “booster”-phenomenon was also observed with different cytochrome P-450 (P-450)-dependent N-demethylation reactions after repeated phenobarbital (PB) administrations. Again the P-450 content was higher than after a single PB administration.

Key words

3-Methylcholanthrene β-Naphthoflavone Phenobarbital Cytochrome P-450 Dealkylation 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • U. Kleeberg
    • 1
  • M. Sommer
    • 1
  • W. Klinger
    • 1
  1. 1.Institute of Pharmacology and ToxicologyFriedrich-Schiller-UniversityJenaGDR

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