Abstract
A single intraperitoneal administration of 3-methylcholanthrene (3 MC) or β-naphthoflavone (BNF) increased aryl hydrocarbon hydroxylase (AHH) and 7-ethoxyresorufin 0-deethylase (EROD) activities. Following a second administration of both inducers 3–4 weeks later, the extent of induction was considerably greater. Such a “booster”-phenomenon was also observed with different cytochrome P-450 (P-450)-dependent N-demethylation reactions after repeated phenobarbital (PB) administrations. Again the P-450 content was higher than after a single PB administration.
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© 1985 Springer-Verlag
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Kleeberg, U., Sommer, M., Klinger, W. (1985). Increased Response of Cytochrome P-450 Dependent Biotransformation Reactions in Rat Liver to Repeated Administration of Inducers. In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_74
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DOI: https://doi.org/10.1007/978-3-642-69928-3_74
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