Abstract
Methylglyoxal (10−5 to 1.5 × 10−4 M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bone S, Pethig R (1979) Electronic and dielectric properties of protein-methylglyoxal complexes. Ciba Found Symp. 67, 83–105
Callec J-J, Satelle DB (1973) A simple technique for monitoring the synaptic actions of pharmacological agents. J exp Biol. 59, 725–738
Eaton DC, Brodwick MS, Oxford GS, Rudy B (1978) Arganine specific reagents remove sodium channel inactivation. Nature. 271, 473–475
Goldenberg M, Gotdenken F, Rothberger CJ (1934) Über Wirkung von methylglyoxal auf Herz und Gefäße. Arch Exp Path Pharmakol. 176, 653–672
Rico JT, Baptista AM (1935) Inactivation of adrenaline by several compounds with aldehyde functions (methylglyoxal, glyceraldehyde). Compt Rend Soc Biol. 118: 1118–1121
Rowan MJ, Chambers PL (1982) The assessment of neurotoxicity using the cockroach nerve cord. Neurobehav Toxicol Teratol. 4, 605–611
Sattelle DB (1981) Acetylcholine receptors in the central nervous system of an insect (Periplaneta americana L.). In Rózsa KS (ed) Adv Physiol Sci, Vol 22. Neurotransmitters in invertebrates. Pergamon Press, Oxford, pp. 31–58
Schauenstein E, Esterbauer H, Zollner H (1977) Aldehydes in biological systems. Their natural occurrence and biological activities. Pion Ltd, London
Szentgyörgyi A (1972) Interaction of glyoxal and methylglyoxal with biogenic amines. Proc Nat Acad Sci USA, 72, 1610–1611
Szentgyörgyi A (1977) The Living State and Cancer. Proc Nat Acad Sci USA, 74, 2844–2847
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1985 Springer-Verlag
About this paper
Cite this paper
Chambers, P.L., Davies, M.G., Rowan, M.J. (1985). The Effects of Methylglyoxal on Central Synaptic Transmission in the Isolated Nerve Cord of the Cockroach (Periplaneta Americana L). In: Chambers, P.L., Cholnoky, E., Chambers, C.M. (eds) Receptors and Other Targets for Toxic Substances. Archives of Toxicology, vol 8. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69928-3_67
Download citation
DOI: https://doi.org/10.1007/978-3-642-69928-3_67
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-13670-5
Online ISBN: 978-3-642-69928-3
eBook Packages: Springer Book Archive