The Effects of Methylglyoxal on Central Synaptic Transmission in the Isolated Nerve Cord of the Cockroach (Periplaneta Americana L)

  • P. L. Chambers
  • M. G. Davies
  • M. J. Rowan
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

Methylglyoxal (10−5 to 1.5 × 10−4 M) was found to have excitatory effects on synaptic transmission in the isolated 6th abdominal ganglion of the cockroach. There was a concentration-dependent depolarization of the giant interneurones which was accompanied by an increase in the amplitude and duration of electrically evoked excitatory postsynaptic potentials. The frequency of spontaneous activity was also increased.

Key words

Methylglyoxal CNS Stimulant Synaptic transmission Cockroach 6th abdominal ganglion Neurophysiology 

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Copyright information

© Springer-Verlag 1985

Authors and Affiliations

  • P. L. Chambers
    • 1
  • M. G. Davies
    • 1
  • M. J. Rowan
    • 1
  1. 1.Department of Pharmacology and TherapeuticsTrinity CollegeDublin 2Ireland

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