Local Toxicity and Pharmacokinetics After Intramuscular or Intralipomatous Injection of Different Drugs in Pigs

  • O. Svendsen
  • L. Blom
  • T. Aaes-Jørgensen
  • J.-J. Larsen
Conference paper
Part of the Archives of Toxicology book series (TOXICOLOGY, volume 8)

Abstract

The question was posed by Cockshott et al. (1982) whether it matters if drugs are given as intramuscular (i.m.) or intralipomatous (i.l.) injection. The thickness of gluteal fat and CT scans of pelvis suggested that the majority of injections intended to be i.m. in fact were delivered i.l.

Local toxicity and pharmacokinetics were studied after i.m. or i.l. injection of different drugs in pigs, which have a subcutaneous layer of fat comparable to that of man. The pigs were killed 1, 3, 7 or 14 days after injection of antibiotics, vitamins or neuroleptics. The tissues at the injection site were examined macroscopically and microscopically. In another series of experiments an aqueous or two different oily preparations of the neuroleptic drug cis(Z)-clopenthixol were given i.m. or i.l. to pigs and a series of blood samples were taken for drug level determination.

The tissue examinations showed that all drugs causing local muscle damage after i.m. injection caused considerably less extensive damage with a faster regeneration after i.l. injection. Only one drug which did not cause muscle damage after i.m. injection, caused some, but slight, irritation after i.l. injection. The pharmacokinetic study showed that there was no difference between plasma concentration time curves after i.m. or i.l. injection.

These findings suggest that i.l. injection of the damaging drugs is better than i.m. injection since i.l. injection causes less local toxicity and the pharmacokinetics are identical. However, further studies are required to substantiate whether this is a general finding.

Key words

Injection Intramuscular Intralipomatous Local toxicity Pharmacokinetics Pigs 

References

  1. Cockshott WP, Thompson GT, Howlett LJ, Seeley ET (1982) Intramuscular or intralipomatous injections? New Engl J Med 307: 356–358.PubMedCrossRefGoogle Scholar
  2. Steiness E, Rasmussen F, Svendsen O, Nielsen P (1978) A comparative study of serum creatine phosphokinase ( CPK) activity in rabbits, pigs and humans after intramuscular injection of local damaging drugs. Acta Pharmacol Toxicol 42: 357–364.Google Scholar
  3. Svendsen O (1983) Local muscle damage and oily vehicles. A study on local reactions in rabbits after intramuscular injection of neuroleptic drugs in aqueous or oily vehicles. Acta Pharmacol Toxicol 52: 298–304.CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1985

Authors and Affiliations

  • O. Svendsen
    • 1
  • L. Blom
    • 1
  • T. Aaes-Jørgensen
    • 1
  • J.-J. Larsen
    • 1
  1. 1.Research LaboratoriesH. Lundbeck A/SCopenhagen-ValbyDenmark

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