The Influence of Ethanol Pretreatment and Social Isolation on Dopamine Release and Locomotor Activity in Mice
Chronic ethanol consumption results in a diminished dopamine release from striatum slices and leads to an enhanced locomotor activity in mice. Individually housed mice showed a preference behaviour for ethanol. Isolation itself diminished both locomotor activity and dopamine release while the combined pretreatment caused enhanced locomotor activity but normal values in dopamine release were seen. It is assumed that the dopamine release inhibition evoked by social isolation may be attributed to an alteration of central dopaminergic function reflected also in behavioural changes. Obviously this functional state diminishes the vulnerability of membrane constituents and prevents the ethanol induced inhibition of release.