Der dosisabhängige Einfluß kardioselektiver und nichtkardioselektiver ß-Rezeptorenblocker auf Stoffwechsel- und Kreislaufparameter während körperlicher Belastung
In 30 healthy, male students the influence of beta-adrenoceptor blocking drugs with different pharmacological properties (acebutolol, metoprolol, Penbutolol, pindolol, propranolol) on heart rate and metabolism was investigated during prolonged physical exercise after acute (4 different doses increasing by factor 2) and chronic application as compared to controls.
Heart rate was significantly reduced during exercise at the lowest dose of each betablocker. Betablockers with intrinsic sympathomimetic activity (ISA) showed a smaller reduction in heart rate than betablockers without ISA.
Beta-adrenoceptor blockade during exercise effected a reduction of blood glucose concentration of about 10–20% as compared to control. There were no remarkable differences between the different betablockers and the applied doses, respectively.
Cholesterol, HDL-cholesterol and triglycerides differed from controls to a small extent only. The concentrations of the free fatty acids were reduced before as well as after exercise as compared to controls. A significant dose-dependence and a difference between the investigated betablockers were not observed.
Dose-Dependent Influence of Cardio-Selective and Non-Selective ß-Receptor Blockers on Metabolic and Cardiovascular Parameters During Physical Exercise
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