Summary
Erythrocytes of different ages can be separated by density centrifugation. There are marked age-dependent differences in oxygen binding. Hemoglobin-oxygen affinity increases with cell age, obviously caused by decreasing diphosphoglycerate concentration, while hemoglobin interaction is reduced. Comparing old and young erythrocytes yields differences in P50 of 6.2 Torr, and in “n„ values (50 SO2) of 0.4. The Bohr coefficient (Δlog PO2/ΔpH) for CO2 acidification is markedly reduced in young compared to old red cells. The adaptive changes in oxygen affinity in endurance trained athletes are partly caused by the lower erythrocyte age resulting from hemolysis and increased erythropoesis.
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© 1984 Springer-Verlag Berlin Heidelberg
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Schmidt, W., Böning, D. (1984). Unterschiede der Sauerstoffbindungseigenschaften von jungen und alten Erythrozyten und ihre Bedeutung für den Ausdauersportler. In: Jeschke, D. (eds) Stellenwert der Sportmedizin in Medizin und Sportwissenschaft/Position of Sports Medicine in Medicine and Sports Science. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69916-0_14
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DOI: https://doi.org/10.1007/978-3-642-69916-0_14
Publisher Name: Springer, Berlin, Heidelberg
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