Zusammenfassung
Die Messung der Hirndurchblutung und des Hirnstoffwechsels mit Indikatorsubstanzen beim Menschen wurden durch die Pionierarbeiten von Kety u. Schmidt ab 1945 erstmals möglich. Durch Gewinnung von Blutproben aus den zu- und abführenden zerebralen Gefäßen war zunächst nur eine Bestimmung für das gesamte Gehirn möglich. Mit der Einführung radioaktiver Indikatorsubstanzen und entsprechender externer Nachweisverfahren konnten dann regionale Messungen durchgeführt werden. In den letzten Jahren haben sich nun durch „single photon emission computer tomography“ (SPECT) und Positronenemissionstomographie (PET) Möglichkeiten zur Untersuchung von Hirndurchblutung und Hirnstoffwechsel mit räumlicher, dreidimensionaler Auflösung eröffnet, und teilweise werden derartige Untersuchungsverfahren auch für dynamische Computertomographie sowie Kernspintomographie (NMR) entwickelt. Diese neuen Verfahren und die wichtigsten bisher erzielten Ergebnisse sollen im folgenden vorgestellt werden.
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Literatur
Baldy-Moulinier M, Ingvar DH, Meldrum BS (eds) (1983) Cerebral blood flow, metabolism and epilepsy. Libbey, London Paris
Baron JC, Bousser MG, Rey A, Guillard A, Comar D, Castaigne P (1981) Reversal of focal “misery-perfusion syndrome” by extra-intracranial arterial bypass in hemodynamic cerebral ischemia. Stroke 12:454–459
Bergström M, Eriksson L, Böhm C, Blomqvist G, Litton J (1983 a) Correction for scattered radiation in a ring detector positron camera by integral transformation of the projections. J Comput Assist Tomogr 7:42–50
Bergström M, Collins VP, Ehrin E et al. (1983 b) Discrepancies in brain tumor extent as shown by computed tomography and positron emission tomography using (68Ga) EDTA, (11C) glucose, and (11C) methionine. J Comput Assist Tomogr 7:1062–1066
Bottomley PA, Hart HR Jr, Edelstein WA et al. (1984) Anatomy and metabolism of the normal human brain studied by magnetic resonance at 1.5 Tesla. Radiology 150:441–446
Brown TR, Kincaid BM, Ugurbil K (1982) NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci USA 79:3523–3526
Frackowiak RSJ, Lenzi GL, Jones T, Heather JD (1980) Quantitative measurement of regional cerebral blood flow and oxygen metabolism in man using 15O and positron emission tomography: Theory, procedure, and normal values. J Comput Assist To-mogr 4:727–736
Gibbs JM, Wise RJS, Leenders KL, Jones T (1984) Evaluation of cerebral perfusion reserve in patients with carotid-artery occlusion. Lancet I:310–314
Haselgrove JC, Subramanian VH, Leigh JS Jr, Gyulai L, Chance B (1983) In vivo one-dimensional imaging of phosphorus metabolites by phosphorus-31 nuclear magnetic resonance. Science 220:1170–1173
Heiss WD, Phelps ME (eds) (1983) Positron emission tomography of the brain. Springer, Berlin Heidelberg New York Tokyo
Heiss WD, Pawlik G, Herholz K, Wagner R, Göldner H, Wienhard K (1984) Regional kinetic constants and cerebral metabolic rate for glucose in normal human volunteers determined by dynamic positron emission tomography of (18F)-2-fluoro-2-deoxy-D-glu-cose. J Cereb Blood Flow Metab 4:212–223
Hilal SK, Maudsley AA, Simon HE et al. (1983) In vivo NMR imaging of tissue sodium in the intact cat before and after acute cerebral stroke. AJNR 4:245–249
Holden JE, Gatley SJ, Hichwa RD, Ip WR, Shaughnessy WJ, Nickles RJ, Polcyn RE (1981) Cerebral blood flow using PET measurements of fluoromethane kinetics. J Nucl Med 22:1084–1088
Holman BL, Lee RGL, Hill TC, Lovett RD, Lister-James J (1984) A comparison of two cerebral perfusion tracers, N-isopropyl I-123 p-iodoamphetamine and I-123 HIPDM, in the human. J Nucl Med 25:25–30
Huang SC, Carson RE, Hoffman EJ, Carson J, McDonald N, Barrio JR, Phelps ME (1983) Quantitative measurement of local cerebral blood flow in humans by positron computed tomography and 15O-water. J Cereb Blood Flow Metab 3:141–153
Ingvar DH, Lassen NA (eds) (1975) Brain work. Munksgaard, Copenhagen
Ingvar DH, Lassen NA (1982) Atraumatic two-dimensional rCBF measurements using stationary detectors and inhalation or intravenous administration of 133-Xenon. J Cereb Blood Flow Metab 2:271–274
Koeppe RA, Holden JE, Polcyn RE, Nickles RJ, Hutchins GD, Weese JL (in press) Absolute quantitation of local cerebral blood flow and partition coefficient without arterial sampling: Theory and validation. J Cereb Blood Flow Metab
Kuhl DE, Phelps ME, Kowell AP, Metter EJ, Selin C, Winter J (1980) Effects of stroke on local cerebral metabolism and perfusion: Mapping by emission computed tomography of 18FDG and 13NH3. Ann Neurol 8:47–60
Kuhl DE, Barrio JR, Huang SC et al. (1982 a) Quantifying local cerebral blood flow by N-isopropyl-p- (123I)iodoamphetamine (IMP) tomography. J Nucl Med 23:196–203
Kuhl DE, Phelps ME, Markham CH, Metter EJ, Riege WH, Winter J (1982 b) Cerebral metabolism and atrophy in Huntington’s disease determined by 18FDG and computed tomographic scan. Ann Neurol 12:425–434
Lammertsma AA, Jones T (1983) Correction for the presence of intravascular oxygen-15 in the steady-state technique for measuring regional oxygen extraction ratio in the brain: 1. Description of the method. J Cereb Blood Flow Metab 3:416–424
Lassen NA, Ingvar DH (1963) Regional cerebral blood flow measurement in man. Arch Neurol 9:615–622
Lassen NA, Henriksen L, Paulson O (1981) Regional cerebral blood flow in stroke by 133Xenon inhalation and emission tomography. Stroke 12:284–288
Leon MJ de, Ferris SH, George AE et al. (1983) Positron emission tomographic studies of aging and Alzheimer disease. AJNR 4:568–571
Litton J, Bergström M, Eriksson L, Bohm C, Blomqvist G, Kesselberg M (1984) Performance study of the PC-384 positron camera system for emission tomography of the brain. J Comput Assist Tomogr 8:74–87
Mazziotta JC, Phelps ME (1984) Human sensory stimulation and deprivation: Positron emission tomographic results and strategies. Ann Neurol [Suppl] 15:50–60
Meyer JS, Hayman LA, Amano T et al. (1981) Mapping local blood flow of human brain by CT scanning during stable Xenon inhalation. Stroke 12:426–436
Mills CM, Brant-Zawadzki M, Crooks LE et al. (1983) Nuclear magnetic resonance: Principles of blood flow imaging. AJNR 4:1161–1166
Naruse S, Horikawa Y, Tanaka C, Hirakawa K, Nishikawa H, Watari H (1984) In vivo measurement of energy metabolism and the concomitant monitoring of electroencephalogram in experimental cerebral ischaemia. Brain Res 296:370–372
Obrist WD, Thompson HK, King CH, Wang HS (1967) Determination of regional cerebral blood flow by inhalation of 133-Xenon. Circ Res 20:124–135
Patronas NJ, Brooks RA, DeLaPaz RL, Smith BH, Kornblith PL, Chiro G Di (1983) Gly-colytic rate (PET) and contrast enhancement (CT) in human cerebral gliomas. AJNR 4:533–535
Phelps ME, Huang SC, Hoffman EJ, Selin C, Sokoloff L, Kuhl DE (1979) Tomographic measurement of local cerebral glucose metabolic rate in humans with (F-18)2-fluoro-2-deoxy-D-glucose: Validation of method. Ann Neurol 6:371–388
Phelps ME, Mazziotta JC, Baxter L, Gerner R (1984) Positron emission tomographic study of affective disorders: Problems and strategies. Ann Neurol [Suppl] 15:149–156
Prichard JW, Alger JR, Behar KL, Petroff OAC, Shulman RG (1983) Cerebral metabolic studies in vivo by 31P NMR. Proc Natl Acad Sci USA 80:2748–2751
Pykett IL (1982) Kernspintomographie: Röntgenbilder ohne Röntgenstrahlen. Spektrum Wissensch 2:40–55
Raichle ME, Martin WRW, Herscovitch P, Mintun MA, Markham J (1983) Brain blood flow measured with intravenous H2 15O. II. Implementation and validation. J Nucl Med 24:790–798
Rhodes CG, Wise RJS, Gibbs JM et al. (1983) In vivo disturbance of the oxidative metabolism of glucose in human cerebral gliomas. Ann Neurol 14:614–626
Roland PE (1982) Cortical regulation of selective attention in man. A regional cerebral blood flow study. J Neurophysiol 48:1059–1078
Singer JR, Crooks LE (1983) Nuclear magnetic resonance blood flow measurements in the human brain. Science 221:654–656
Sokoloff L, Reivich M, Kennedy C et al. (1977) The (14C)deoxyglucose method for the measurement of local cerebral glucose utilization: Theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28:897–916
Thulborn KR, Boulay GH Du, Duchen LW, Radda G (1982) A 31P nuclear magnetic resonance in vivo study of cerebral ischaemia in the gerbil. J Cereb Blood Flow Metab 2:299–306
Tomita M, Gotoh F (1981) Local cerebral blood flow values as estimated with diffusible tracers: Validity of assumptions in normal and ischemic tissue. J Cereb Blood Flow Metab 1:403–411
Veall N, Mallett BL (1965) The partition of tracer amounts of Xenon between human blood and brain tissues at 37 °C. Phys Med Biol 10:375–380
Wise RJS, Rhodes CG, Gibbs JM, Hatazawa J, Palmer T, Frackowiak RSJ, Jones T (1983) Disturbance of oxidative metabolism of glucose in recent human cerebral infarcts. Ann Neurol 14:627–637
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Herholz, K., Heiss, WD., Pawlik, G., Wienhard, K. (1985). Neue Verfahren zur Messung von Durchblutung und Metabolismus des Gehirns. In: Rügheimer, E., Pasch, T. (eds) Notwendiges und nützliches Messen in Anästhesie und Intensivmedizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69893-4_3
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DOI: https://doi.org/10.1007/978-3-642-69893-4_3
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