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Patient — Infektion — Immunglobulin pp 60–68Cite as

Infektionen durch Cytomegalievirus — klassisch-virologische Grundlagen und molekularbiologische Perspektiven

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Zusammenfassung

Infektionen durch das Cytomegalievirus (CMV; Zytomegalie-Virus) sind weit verbreitet. Nahezu alle Disziplinen der Medizin sind betroffen. Kein zweites humanpathogenes Virus ist mit so vielfältigen, oft uncharakteristischen klinischen Erscheinungsformen assoziiert; häufig ist ohne moderne virologische Laborverfahren keine Diagnosestellung möglich. Die Infektion kann einerseits vollkommen symptomlos verlaufen, andererseits eine schwerwiegende Erkrankung hervorrufen; man kann lokalisierte, organbezogene Formen von generalisierten Manifestationen unterscheiden. Patienten mit malignen Erkrankungen und Immunsupprimierte stellen eine hohe Risikogruppe für CMV-Infektionen dar.

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Literatur

  1. Adler SP (1983) Transfusion-associated cytomegalovirus infections. Rev Infect Dis 6: 977

    Article  Google Scholar 

  2. Chou S, Merigan TC (1983) Rapid detection and quantitation of human cytomegalovirus in urine through DNA hybridization. N Engl J Med 308: 921

    Article  PubMed  CAS  Google Scholar 

  3. Cheeseman SH, Rubin RH, Stewart JA et al (1979) Controlled clinical trial of prophylactic human-leukocyte interferon in renal transplantation. Effect on cytomegalovirus and herpes simplex virus infections. N Engl J Med 300: 1345

    Article  PubMed  CAS  Google Scholar 

  4. Dijkmans BAC, Versteeg J, Kaufmann RH et al (1979) Treatment of cytomegalovirus Pneumonitis with hyperimmune plasma. Lancet I: 820

    Article  Google Scholar 

  5. Drew WL, Miner RC, Ziegler JL et al. (1982) Cytomegalovirus and Kaposi’s sarcoma in young homosexual men. Lancet II: 125

    Article  Google Scholar 

  6. Fleckenstein B, Müller I, Collins J (1982) Cloning of the complete human cytomegalovirus genome in cosmids. Gene 18: 39–46

    Article  PubMed  CAS  Google Scholar 

  7. Gluckman E, Devergie A, Melo R et al. (1983) Prophylaxis of herpes infections after bone-marrow-transplantation by oral acyclovir. Lancet II: 706–708

    Article  Google Scholar 

  8. Hirsch MS, Schooley RT (1983) Treatment of herpesvirus infections. N Engl J Med 309: 1034–1039

    Article  PubMed  CAS  Google Scholar 

  9. Huang ES, Roche RK (1978) Cytomegalovirus DNA and adenocarcinoma of the colone: Evidence for latent viral infection. Lancet I: 957–960

    Article  Google Scholar 

  10. Jahn G, Knust E, Schmolla H, Sarre T, Nelson JA, McDougall JK, Fleckenstein B (1984) Predominant immediate early transcripts of human cytomegalovirus strain AD169. J Virol 49: 363–370

    PubMed  CAS  Google Scholar 

  11. Melnick JL, Dreesman GR, McCollum CH, Petric BL, Burek J, De Bakey ME (1983) Cytomegalo virus antigen within human arterial smooth muscle cells. Lancet II: 644–647

    Article  Google Scholar 

  12. Melnick JL, Lewis R, Wimberley J, Kaufman RH, Adam E (1978) Association of cytomegalo virus infection with cervical cancer: Isolation of CMV from cell cultures derived from cervical biopsy. Intervirology 10: 115–119

    Article  PubMed  CAS  Google Scholar 

  13. Meyers JD, Leszynski J, Zaia JA et al (1983) Prevention of cytomegalovirus infection by cytomegalovirus immune globulin after marrow transplantation. Ann Intern Med 98: 442–446

    PubMed  CAS  Google Scholar 

  14. Nagington J (1971) Cytomegalovirus antibody production in renal transplant patients. J Hyg (Camb) 69: 645–660

    Article  CAS  Google Scholar 

  15. Nelson JA, Fleckenstein B, Jahn G, Galloway DA, McDougall JK (1984) Structure of the transforming region of human cytomegalovirus strain AD 169. J Virol 49: 109–115

    PubMed  CAS  Google Scholar 

  16. Nicholls AJ, Brown CB, Edward N, Cuthbertson B, Yap PL, McClelland DBL (1983) Hyperimmune immunglobulin for cytomegalovirus infections. Lancet I: 532–533

    Article  Google Scholar 

  17. Nowak B, Sullivan C, Sarnow P, Thomas R, Bricout F, Nicolas JC, Fleckenstein B, Levine AJ (1984) Characterization of monoclonal antibodies and polyclonal immune sera directed against human cytomegalovirus virion proteins. Virology 132: 325–338

    Article  PubMed  CAS  Google Scholar 

  18. Pereira L, Hoffman M, Gallo D, Cremer N (1982) Monoclonal antibodies to human cytomegalovirus: Three surface memrane proteins with unique immunological electrophoretic properties specify cross-reactive determinants. Infect Immun 36: 924–932

    PubMed  CAS  Google Scholar 

  19. Rüger R, Bornkamm GW, Fleckenstein B (1984) Human cytomegalovirus DNA sequences with homologies to the cellular genome. J General Virol (in press)

    Google Scholar 

  20. Rüger R, Burmester GR, Kalden JR, Bienzle U, Braun R, Safai B, Sterry W, Fleckenstein B (1984) Search for human cytomegalovirus DNA in Kaposi sarcomas and heamatopoietic cells from homosexual men with AIDS or unexplained lymphadenopathy. In UCLA Symposia on Molecular and Cellular Biology, Vol. 16. Acquired Immune Deficiency Syndrome, eds. M. Gottlieb and J. Groopman, Alan Liss, Inc., New York (in press)

    Google Scholar 

  21. Sanford EJ, Geder L, Laychock A, Rohner TJ, Rapp F (1977) Evidence for the association of cytomegalovirus with carcinoma of the prostate. J Urol 118: 789–792

    PubMed  CAS  Google Scholar 

  22. Schmitz H, Doerr HW, Kampa D, Vogt A (1977) Solidphase enzyme immunoassay for immunoglobulin M antibodies to cytomegalovirus. J Clin Microbiol 5: 629–634

    PubMed  CAS  Google Scholar 

  23. Stagno S, Pass RF, Deworsky ME et al (1982) Congenital cytomegalovirus infection. N Engl J Med 306: 945–949

    Article  PubMed  CAS  Google Scholar 

  24. Tamashiro JC, Hock LJ, Spector DH (1982) Construction of a cloned library of the Eco RI fragments from the human cytomegalovirus genome (strain AD 169) J Virol 42: 547–557

    PubMed  CAS  Google Scholar 

  25. Thomsen DR, Stinski MF (1981) Cloning of the human cytomegalovirus genome as endonuclease Xbal fragments. Gene 16: 207–216

    Article  PubMed  CAS  Google Scholar 

  26. Volpi A, Whitley RJ, Ceballos R, Stagno S (1983) Rapid diagnosis of pneumonia due to cytomegalovirus with specific monoclonal antibodies. J Infect Dis 147: 1119–1120

    Article  PubMed  CAS  Google Scholar 

  27. Wade JC, McGuffin RW, Springmeyer SC, Newton B, Singer JW, Meyers JD (1983) Treatment of cytomegaloviral pneumonia with high-dose acyclovir and human leukocyte interferon. J Infect Dis 148: 557–562

    Article  PubMed  CAS  Google Scholar 

  28. Wathen MW, Stinski MF (1982) Temporal patterns of human cytomegalovirus transcription: mapping the viral RNAs synthesized at immediate early, early and late times after infection. J Virol 41: 462–477

    PubMed  CAS  Google Scholar 

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Authors
  1. G. Jahn
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  2. B. Fleckenstein
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Editor information

Editors and Affiliations

  1. Zentrum der Kinderheilkunde, Klinikum der J.-W.-Goethe-Universität, Theodor-Stern-Kai 7, 6000, Frankfurt 70, Germany

    Bernhard Kornhuber

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© 1984 Springer-Verlag Berlin Heidelberg

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Jahn, G., Fleckenstein, B. (1984). Infektionen durch Cytomegalievirus — klassisch-virologische Grundlagen und molekularbiologische Perspektiven. In: Kornhuber, B. (eds) Patient — Infektion — Immunglobulin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69877-4_9

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  • DOI: https://doi.org/10.1007/978-3-642-69877-4_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13607-1

  • Online ISBN: 978-3-642-69877-4

  • eBook Packages: Springer Book Archive

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