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Disruption and Activation of the c-myb Locus by M-MuLV Insertion in Plasmacytoid Lymphosarcomas Induced by Pristane and Abelson Viruses

  • G. L. C. Shen-Ong
  • E. P. Reddy
  • M. Potter
  • J. F. Mushinski
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)

Abstract

The c-myb proto-oncogene is the cellular homolog of the avian myeloblastosis virus oncogene (v-myb) (Roussel et al., 1979; Souza et al., 1980a; Bergman et al., 1981). The boundaries of c-myb are not yet known; however, studies have shown that the v-myb sequence is transduced from a portion of the coding region of c-myb into the avian myeloblastosis virus (AMV) (Klempnauer and Bishop 1983). AMV is a retrovirus that causes myeloblastic or monocytic leukemia in chickens and transforms myelomonocytic hematopoietic cells in culture (Moscovici 1975). The v-myb sequence is thought to be essential for the oncogenic potential of AMV (Duesberg et al., 1980; Souza 1980a; Gonda et al., 1981) and it appears that only certain target cells are responsive to the v-myb gene product (Moscovici 1975).

Keywords

Long Terminal Repeat Murine Leukemia Virus Monocytic Leukemia Avian Myeloblastosis Virus Long Terminal Repeat Sequence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • G. L. C. Shen-Ong
    • 1
  • E. P. Reddy
    • 2
  • M. Potter
    • 1
  • J. F. Mushinski
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA

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