Disruption and Activation of the c-myb Locus by M-MuLV Insertion in Plasmacytoid Lymphosarcomas Induced by Pristane and Abelson Viruses

  • G. L. C. Shen-Ong
  • E. P. Reddy
  • M. Potter
  • J. F. Mushinski
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)


The c-myb proto-oncogene is the cellular homolog of the avian myeloblastosis virus oncogene (v-myb) (Roussel et al., 1979; Souza et al., 1980a; Bergman et al., 1981). The boundaries of c-myb are not yet known; however, studies have shown that the v-myb sequence is transduced from a portion of the coding region of c-myb into the avian myeloblastosis virus (AMV) (Klempnauer and Bishop 1983). AMV is a retrovirus that causes myeloblastic or monocytic leukemia in chickens and transforms myelomonocytic hematopoietic cells in culture (Moscovici 1975). The v-myb sequence is thought to be essential for the oncogenic potential of AMV (Duesberg et al., 1980; Souza 1980a; Gonda et al., 1981) and it appears that only certain target cells are responsive to the v-myb gene product (Moscovici 1975).


Long Terminal Repeat Murine Leukemia Virus Monocytic Leukemia Avian Myeloblastosis Virus Long Terminal Repeat Sequence 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • G. L. C. Shen-Ong
    • 1
  • E. P. Reddy
    • 2
  • M. Potter
    • 1
  • J. F. Mushinski
    • 1
  1. 1.Laboratory of GeneticsNational Cancer InstituteBethesdaUSA
  2. 2.Laboratory of Cellular and Molecular BiologyNational Cancer InstituteBethesdaUSA

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