Abstract
The c-myb proto-oncogene is the cellular homolog of the avian myeloblastosis virus oncogene (v-myb) (Roussel et al., 1979; Souza et al., 1980a; Bergman et al., 1981). The boundaries of c-myb are not yet known; however, studies have shown that the v-myb sequence is transduced from a portion of the coding region of c-myb into the avian myeloblastosis virus (AMV) (Klempnauer and Bishop 1983). AMV is a retrovirus that causes myeloblastic or monocytic leukemia in chickens and transforms myelomonocytic hematopoietic cells in culture (Moscovici 1975). The v-myb sequence is thought to be essential for the oncogenic potential of AMV (Duesberg et al., 1980; Souza 1980a; Gonda et al., 1981) and it appears that only certain target cells are responsive to the v-myb gene product (Moscovici 1975).
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References
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Shen-Ong, G.L.C., Reddy, E.P., Potter, M., Mushinski, J.F. (1984). Disruption and Activation of the c-myb Locus by M-MuLV Insertion in Plasmacytoid Lymphosarcomas Induced by Pristane and Abelson Viruses. In: Potter, M., Melchers, F., Weigert, M. (eds) Oncogenes in B-Cell Neoplasia. Current Topics in Microbiology and Immunology, vol 113. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69860-6_9
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DOI: https://doi.org/10.1007/978-3-642-69860-6_9
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