Tlym-I, a Stage Specific Transforming Gene Shares Homology with MHC I Region Genes

  • M.-A. Lane
  • H. A. F. Stephens
  • K. M. Doherty
  • M. B. Tobin
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 113)

Abstract

We previously reported the identification of five different stage specific transforming genes activated in T and B-lymphoid neoplasms (Lane, 1982). These genes are evolutionarily We11-conserved between mouse and man and are expressed in multiple neoplasms representative of particular stages of normal lymphoid cellular differentiation.

Keywords

Lymphoma Leukemia Polysaccharide Hunt Transferrin 

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References

  1. Brickell PM, Latchman DS, Murphy D, Willison K, Rigby PWJ (1983) Activation of a Qa/TLa class I major histocompatibility antigen gene is a general feature of oncogenesis in the mouse. Nature 306: 756–760PubMedCrossRefGoogle Scholar
  2. Cooper GM, Neiman PE. Personal communicationGoogle Scholar
  3. Diamond A, Cooper GM, Ritz J, Lane MA (1983) Identification and molecular cloning of the human Blym transforming gene activated in Burkitt’s lymphomas. Nature 305: 112–116PubMedCrossRefGoogle Scholar
  4. Diamond A, Cooper GM. Personal communicationGoogle Scholar
  5. Evans GA, Margulies DH, Camerini-Otero RD, Ozato K, Seidman JG (1982) Structure and expression of a mouse major histocompatibility antigen gene H-2L∂. Proc Natl Acad Sei USA 79: 1994–1998CrossRefGoogle Scholar
  6. Flaherty L (1980) TLA-region antigens. In: The role of the major histocompatibility complex in immunology. Garland STPM Press, New York, p 33Google Scholar
  7. Goubin G, Goldman DS, Luce J, Neiman PE, Cooper GM (1983) Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA. Nature 302: 114–119PubMedCrossRefGoogle Scholar
  8. Lane MA, Sainten A, Cooper GM (1982) Stage-specific transforming genes of human and mouse B- and T-lymphocyte neoplasms. Cell 28: 873 –880PubMedCrossRefGoogle Scholar
  9. Lane MA, Sainten A, Doherty KM, Cooper GM (1984) Isolation and characterization of a stage specific transforming gene, Tlym-1, from T-cell lymphomas. Proc Natl Acad Sei USA (in press)Google Scholar
  10. Steinmetz M, Winoto A, Minard K, Hood L (1981) Clusters of genes encoding mouse transplantation antigens. Cell 28: 489–498CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1984

Authors and Affiliations

  • M.-A. Lane
    • 1
    • 2
  • H. A. F. Stephens
    • 1
    • 2
  • K. M. Doherty
    • 1
  • M. B. Tobin
    • 1
  1. 1.Laboratory of Molecular ImmunobiologyDana-Farber Cancer InstituteUSA
  2. 2.Dept. of PathologyHarvard Medical SchoolBostonUSA

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